Literature DB >> 27506281

Heterodinuclear Pt(iv)-Ru(ii) anticancer prodrugs to combat both drug resistance and tumor metastasis.

Lili Ma1, Rong Ma, Zhigang Wang, Shek-Man Yiu, Guangyu Zhu.   

Abstract

A novel approach to design bimetallic anticancer drug candidates with the capability to combat both drug resistance and tumor metastasis is reported. These water-soluble bifunctional Pt(iv)-Ru(ii) heterodinuclear complexes with a unique mode of action display up to 2-orders of magnitude enhanced cytotoxicity in cisplatin-resistant cells and significantly impede cancer cell migration.

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Year:  2016        PMID： 27506281     DOI： 10.1039/c6cc04354b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

1.  A heterometallic ruthenium-gold complex displays antiproliferative, antimigratory, and antiangiogenic properties and inhibits metastasis and angiogenesis-associated proteases in renal cancer.

Authors:  Benelita T Elie; Yuriy Pechenyy; Fathema Uddin; María Contel
Journal:  J Biol Inorg Chem       Date:  2018-03-05       Impact factor: 3.358

Review 2.  Ruthenium(ii)-arene complexes as anti-metastatic agents, and related techniques.

Authors:  Chanchal Sonkar; Sayantan Sarkar; Suman Mukhopadhyay
Journal:  RSC Med Chem       Date:  2021-09-15

3.  Bimetallic titanocene-gold phosphane complexes inhibit invasion, metastasis, and angiogenesis-associated signaling molecules in renal cancer.

Authors:  Benelita T Elie; Jacob Fernández-Gallardo; Natalia Curado; Mike A Cornejo; Joe W Ramos; María Contel
Journal:  Eur J Med Chem       Date:  2018-10-17       Impact factor: 6.514

4.  Cytotoxic (salen)ruthenium(iii) anticancer complexes exhibit different modes of cell death directed by axial ligands.

Authors:  Cai Li; Kwok-Wa Ip; Wai-Lun Man; Dan Song; Ming-Liang He; Shek-Man Yiu; Tai-Chu Lau; Guangyu Zhu
Journal:  Chem Sci       Date:  2017-07-31       Impact factor: 9.825

5.  Ruthenafuran Complexes Supported by the Bipyridine-Bis(diphenylphosphino)methane Ligand Set: Synthesis and Cytotoxicity Studies.

Authors:  Chi-Fung Yeung; Sik-Him Tang; Zhe Yang; Tsun-Yin Li; Ka-Kit Li; Yuen-Man Chan; Hau-Lam Shek; Kai-Wa Io; King-Ting Tam; Shek-Man Yiu; Man-Kit Tse; Chun-Yuen Wong
Journal:  Molecules       Date:  2022-03-05       Impact factor: 4.411

6.  Systematic Study on the Cytotoxic Potency of Commonly Used Dimeric Metal Precursors in Human Cancer Cell Lines.

Authors:  Heiko Geisler; Sophia Harringer; Dominik Wenisch; Richard Urban; Michael A Jakupec; Wolfgang Kandioller; Bernhard K Keppler
Journal:  ChemistryOpen       Date:  2022-02-24       Impact factor: 2.630

7.  Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism.

Authors:  Roshan Satange; Shih-Hao Kao; Ching-Ming Chien; Shan-Ho Chou; Chi-Chien Lin; Stephen Neidle; Ming-Hon Hou
Journal:  Nucleic Acids Res       Date:  2022-08-26       Impact factor: 19.160

Review 8.  Strategies for the Improvement of Metal-Based Chemotherapeutic Treatments.

Authors:  Damiano Cirri; Francesco Bartoli; Alessandro Pratesi; Emma Baglini; Elisabetta Barresi; Tiziano Marzo
Journal:  Biomedicines       Date:  2021-05-04
  8 in total

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