| Literature DB >> 27505668 |
Virginie Penard-Lacronique1, Olivier A Bernard2.
Abstract
IDH mutants cause aberrant DNA and histone methylation and contribute to hematological and neuronal malignancies. In this issue of Cancer Cell, Inoue et al. describe a potential specific effect of IDH1 mutations that reduces Atm expression via inhibition of H3K9 demethylases, which may represent a first step toward cellular transformation.Entities:
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Year: 2016 PMID： 27505668 DOI： 10.1016/j.ccell.2016.07.008
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743