Literature DB >> 27505095

Bcl-2 family proteins: master regulators of cell survival.

Jozef Hatok, Peter Racay.   

Abstract

The most prominent function of proteins of the Bcl-2 family is regulation of the initiation of intrinsic (mitochondrial) pathways of apoptosis. However, recent research has revealed that in addition to regulation of mitochondrial apoptosis, proteins of the Bcl-2 family play important roles in regulating other cellular pathways with a strong impact on cell survival like autophagy, endoplasmic reticulum (ER) stress response, intracellular calcium dynamics, cell cycle progression, mitochondrial dynamics and energy metabolism. This review summarizes the recent knowledge about functions of Bcl-2 family proteins that are related to cell survival.

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Year:  2016        PMID： 27505095     DOI： 10.1515/bmc-2016-0015

Source DB:  PubMed          Journal:  Biomol Concepts        ISSN： 1868-5021


  34 in total

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Journal:  Cell Cycle       Date:  2020-08-20       Impact factor: 4.534

2.  Structural insights into the interaction of the conserved mammalian proteins GAPR-1 and Beclin 1, a key autophagy protein.

Authors:  Yue Li; Yuting Zhao; Minfei Su; Karen Glover; Srinivas Chakravarthy; Christopher L Colbert; Beth Levine; Sangita C Sinha
Journal:  Acta Crystallogr D Struct Biol       Date:  2017-08-29       Impact factor: 7.652

3.  Transcription factors IRF8 and PU.1 are required for follicular B cell development and BCL6-driven germinal center responses.

Authors:  Hongsheng Wang; Shweta Jain; Peng Li; Jian-Xin Lin; Jangsuk Oh; Chenfeng Qi; Yuanyuan Gao; Jiafang Sun; Tomomi Sakai; Zohreh Naghashfar; Sadia Abbasi; Alexander L Kovalchuk; Silvia Bolland; Stephen L Nutt; Warren J Leonard; Herbert C Morse
Journal:  Proc Natl Acad Sci U S A       Date:  2019-04-18       Impact factor: 11.205

4.  A proteomic analysis of Bcl-2 regulation of cell cycle arrest: insight into the mechanisms.

Authors:  Xing DU; Jingjing Xiao; Xufeng Fu; Bo Xu; Hang Han; Yin Wang; Xiuying Pei
Journal:  J Zhejiang Univ Sci B       Date:  2021-10-15       Impact factor: 3.066

5.  The molecular mechanisms of vulpinic acid induced programmed cell death in melanoma.

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Journal:  Mol Biol Rep       Date:  2022-08-12       Impact factor: 2.742

6.  Thymoquinone Alterations of the Apoptotic Gene Expressions and Cell Cycle Arrest in Genetically Distinct Triple-Negative Breast Cancer Cells.

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Review 7.  Molecular Mechanisms of Epigenetic Regulation, Inflammation, and Cell Death in ADPKD.

Authors:  Ewud Agborbesong; Linda Xiaoyan Li; Lu Li; Xiaogang Li
Journal:  Front Mol Biosci       Date:  2022-06-29

8.  Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline.

Authors:  Zhen Ren; Si Chen; Ji-Eun Seo; Xiaoqing Guo; Dongying Li; Baitang Ning; Lei Guo
Journal:  Toxicol In Vitro       Date:  2020-08-28       Impact factor: 3.500

9.  Naa10p Enhances Chemosensitivity to Cisplatin in Oral Squamous Cell Carcinoma Cells.

Authors:  Lichun Sun; Kaixin Wang; Lu Peng; Jinfang Zhang; Jie Yang; Juan Zhao; Jiang Xu; Jun Zheng; Yan Zeng
Journal:  Cancer Manag Res       Date:  2021-02-22       Impact factor: 3.989

10.  Exploring the Structure-Activity Relationship and Mechanism of a Chromene Scaffold (CXL Series) for Its Selective Antiproliferative Activity toward Multidrug-Resistant Cancer Cells.

Authors:  Tengfei Bian; Kavitha Chandagirikoppal Vijendra; Yi Wang; Amy Meacham; Santanu Hati; Christopher R Cogle; Haifeng Sun; Chengguo Xing
Journal:  J Med Chem       Date:  2018-07-25       Impact factor: 8.039
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