Ganesh Kulkarni1, Esther Priyadarshini Sakki2, Yennavaram Vijay Kumar3, Sadananda Kolimi4, Ravi Perika1, Kalepu Venkata Karthik5, Kandukuri Mahesh Kumar6, Venumbaka Siva Kalyan7. 1. Senior Lecturer, Department of Oral Pathology, Malla Reddy Institute of Dental Sciences , Hyderabad, Telangana, India . 2. Senior Lecturer, Department of Oral Pathology, Meghana Institute of Dental sciences , Nizamabad, Telangana, India . 3. Associate Professor, Department of Public Health Dentistry, MNR Dental College and Hospital , Sangareddy, Telangana, India . 4. Assistant Professor, Department of Periodontics, Government Dental College and Research Institute , VIMS, Bellary, Karnataka, India . 5. Senior Lecturer, Department of Oral Pathology, SVS Institute of Dental Sciences , Mahbubnagar, Telangana, India . 6. Assistant Professor, Department of Pathology, Malla Reddy Institute of Medical Sciences , Hyderabad, Telangana, India . 7. Reader, Department of Public Health Dentistry, Mamatha Dental College , Khammam, Telangana, India .
Abstract
INTRODUCTION: Langerhan's Cells (LCs) are dendritic cells of the oral epithelium which play a role in a series of oral lesions from gingivitis to oral cancer. Oral Lichen Planus (OLP) is an oral mucosal T-lymphocyte mediated immunologic reaction to an unidentified putative antigen or allergen. AIM: The aim of this study was to quantify the presence of immature LCs in OLP comparing them with normal epithelium. MATERIALS AND METHODS: A retrospective study using 30 of OLP cases were conducted. Immunohistochemistry was performed using polyclonal anti-CD1a antibodies to identify LCs in 10 cases of normal tissue and 30 samples of OLP. The distribution of LCs among lesional tissue and normal mucosa was analysed using Mann-Whitney U test. RESULTS: LC population in OLP was significantly higher when compared to the normal epithelium (p<0.001). CONCLUSION: The increase in LCs indicates the active role played during the antigen detection in OLP and subsequent presentation to T-lymphocytes.
INTRODUCTION: Langerhan's Cells (LCs) are dendritic cells of the oral epithelium which play a role in a series of oral lesions from gingivitis to oral cancer. Oral Lichen Planus (OLP) is an oral mucosal T-lymphocyte mediated immunologic reaction to an unidentified putative antigen or allergen. AIM: The aim of this study was to quantify the presence of immature LCs in OLP comparing them with normal epithelium. MATERIALS AND METHODS: A retrospective study using 30 of OLP cases were conducted. Immunohistochemistry was performed using polyclonal anti-CD1a antibodies to identify LCs in 10 cases of normal tissue and 30 samples of OLP. The distribution of LCs among lesional tissue and normal mucosa was analysed using Mann-Whitney U test. RESULTS: LC population in OLP was significantly higher when compared to the normal epithelium (p<0.001). CONCLUSION: The increase in LCs indicates the active role played during the antigen detection in OLP and subsequent presentation to T-lymphocytes.
Authors: C Scully; M Beyli; M C Ferreiro; G Ficarra; Y Gill; M Griffiths; P Holmstrup; S Mutlu; S Porter; D Wray Journal: Crit Rev Oral Biol Med Date: 1998