Santosh Kumar1, Ajay Kumar Chaudhary2, Prithvi Kumar Singh3, Reetu Verma2, Girish Chandra4, Vinod Kumar Bhatia4, Dinesh Singh4, Jaishri Bogra4. 1. Resident, Department of Anaesthesiology, King George's Medical University , U.P., Lucknow, India . 2. Associate Professor, Department of Anaesthesiology, King George's Medical University , U.P., Lucknow, India . 3. Ph.D. Scholar, Department of Anaesthesiology, King George's Medical University , U.P., Lucknow, India . 4. Professor, Department of Anaesthesiology, King George's Medical University , U.P., Lucknow, India .
Abstract
INTRODUCTION:Buprenorphine is a semi-synthetic derivative of thebaine; its low concentration is sufficient to provide effective pain relief. AIM: To evaluate the efficacy of transdermal buprenorphine patch in postoperative pain management. MATERIALS AND METHODS: After ethical approval and taking informed consent from the patients, they were randomized into three groups (n=30 in each group) using a computer generated random number table. Group A: placebo patch; Group B: buprenorphine (10mg) patch and Group C: buprenorphine (20mg) patch. Haemodynamic and analgesic effects were compared by using analysis of variance (ANOVA) followed by Turkey's post hoc test. The proportion of side effects was compared using the Chi-square test. RESULTS:Haemodynamic changes were not statistically different in all the three groups A, B and C, whereas at the end of surgery VAS score of Group A subjects was significantly higher (4.93±0.98) as compared to Group B (1.73±0.64) and Group C (1.40±0.50). On 2(nd) postoperative day, no pain was reported by the Group C patients and on 4(th) day after surgery, no pain was reported by Group B patients. CONCLUSION: The transdermal buprenorphine patch (20mg) was effective in attenuating postoperative pain, maintaining haemodynamic stability requiring no rescue analgesia, with fewer postoperative rescue analgesic requirements in low dose of buprenorphine patch (10mg) group.
RCT Entities:
INTRODUCTION:Buprenorphine is a semi-synthetic derivative of thebaine; its low concentration is sufficient to provide effective pain relief. AIM: To evaluate the efficacy of transdermal buprenorphine patch in postoperative pain management. MATERIALS AND METHODS: After ethical approval and taking informed consent from the patients, they were randomized into three groups (n=30 in each group) using a computer generated random number table. Group A: placebo patch; Group B: buprenorphine (10mg) patch and Group C: buprenorphine (20mg) patch. Haemodynamic and analgesic effects were compared by using analysis of variance (ANOVA) followed by Turkey's post hoc test. The proportion of side effects was compared using the Chi-square test. RESULTS: Haemodynamic changes were not statistically different in all the three groups A, B and C, whereas at the end of surgery VAS score of Group A subjects was significantly higher (4.93±0.98) as compared to Group B (1.73±0.64) and Group C (1.40±0.50). On 2(nd) postoperative day, no pain was reported by the Group C patients and on 4(th) day after surgery, no pain was reported by Group B patients. CONCLUSION: The transdermal buprenorphine patch (20mg) was effective in attenuating postoperative pain, maintaining haemodynamic stability requiring no rescue analgesia, with fewer postoperative rescue analgesic requirements in low dose of buprenorphine patch (10mg) group.
Entities:
Keywords:
Analgesia; Haemodynamic; Patch; Transdermal delivery system
Authors: Allan Gordon; Saifudin Rashiq; Dwight E Moulin; Alexander J Clark; André D Beaulieu; John Eisenhoffer; Paula S Piraino; Patricia Quigley; Zoltan Harsanyi; Andrew C Darke Journal: Pain Res Manag Date: 2010 May-Jun Impact factor: 3.037
Authors: Stanislav Oifa; Tatiana Sydoruk; Ian White; Margaret P Ekstein; Nissim Marouani; Shoshana Chazan; Yehuda Skornick; Avi A Weinbroum Journal: Clin Ther Date: 2009-03 Impact factor: 3.393