Literature DB >> 27504323

Simple Limbal Epithelial Transplantation in Acid Injury and Severe Dry Eye.

Sudesh Kumar Arya1, Anubha Bhatti2, Amit Raj3, Ravi Kant Bamotra4.   

Abstract

The epithelial cells of cornea constantly undergo renewal and regeneration and the stem cells responsible for renewal resides within basal epithelium at the limbus in palisades of Vogt. Simple limbal epithelial transplantation (SLET) is a simplified technique for limbal stem cell deficiency and it combines the benefits of both conjunctival limbal autografting and cultivated limbal epithelial transplantation by being single-stage and utilizing minimal donor tissue. We will be discussing two cases of ocular surface disorder which were managed successfully by new technique simple limbal epithelial transplantation. Two patients one with unilateral Limbal Stem Cell Deficiency (LSCD) following acid injury and other with bilateral LSCD due to severe dry eye underwent limbal epithelial transplantation using the SLET method after taking prior consent for the procedure. Success was termed complete when a completely epithelialized, avascular and stable corneal surface was seen. The follow up examinations were done on first day, at 1 week, 2 weeks, 4 weeks and at 3 months after the surgery. A completely epithelialised, avascular and stable corneal surface was achieved by 4 weeks in both patients. Simple limbal epithelial transplantation is a new technique which is simple, cheap and easily affordable and it has decreased the dependence on stem cell laboratory.

Entities:  

Keywords:  Chemical injury; Ocular surface disorder; Stem cell transplant

Year:  2016        PMID: 27504323      PMCID: PMC4963683          DOI: 10.7860/JCDR/2016/19306.7997

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  8 in total

1.  A new classification of ocular surface burns.

Authors:  H S Dua; A J King; A Joseph
Journal:  Br J Ophthalmol       Date:  2001-11       Impact factor: 4.638

Review 2.  Limbal stem cell transplantation.

Authors:  Merle Fernandes; Virender S Sangwan; Srinivas K Rao; Surendra Basti; Mittanamalli S Sridhar; Aashish K Bansal; Harminder S Dua
Journal:  Indian J Ophthalmol       Date:  2004-03       Impact factor: 1.848

3.  Role of the pericorneal papillary structure in renewal of corneal epithelium.

Authors:  M Davanger; A Evensen
Journal:  Nature       Date:  1971-02-19       Impact factor: 49.962

Review 4.  Identification and characterization of limbal stem cells.

Authors:  Ursula Schlötzer-Schrehardt; Friedrich E Kruse
Journal:  Exp Eye Res       Date:  2005-09       Impact factor: 3.467

5.  Simple limbal epithelial transplantation (SLET): a novel surgical technique for the treatment of unilateral limbal stem cell deficiency.

Authors:  Virender S Sangwan; Sayan Basu; Sheila MacNeil; Dorairajan Balasubramanian
Journal:  Br J Ophthalmol       Date:  2012-02-10       Impact factor: 4.638

6.  Modified simple limbal epithelial transplantation using cryopreserved amniotic membrane for unilateral limbal stem cell deficiency.

Authors:  Guillermo Amescua; Marwan Atallah; Neda Nikpoor; Anat Galor; Victor L Perez
Journal:  Am J Ophthalmol       Date:  2014-06-14       Impact factor: 5.258

7.  In-vivo expansion of autologous limbal stem cell using simple limbal epithelial transplantation for treatment of limbal stem cell deficiency.

Authors:  Ikeda Lal; Bhavik Uttam Panchal; Sayan Basu; Virender S Sangwan
Journal:  BMJ Case Rep       Date:  2013-05-22

8.  Successful autologous simple limbal epithelial transplantation (SLET) in previously failed paediatric limbal transplantation for ocular surface burns.

Authors:  Swapnil Bhalekar; Sayan Basu; Ikeda Lal; Virender S Sangwan
Journal:  BMJ Case Rep       Date:  2013-05-10
  8 in total
  7 in total

1.  Ultrahigh-resolution OCT imaging of the human cornea.

Authors:  René M Werkmeister; Sabina Sapeta; Doreen Schmidl; Gerhard Garhöfer; Gerald Schmidinger; Valentin Aranha Dos Santos; Gerold C Aschinger; Isabella Baumgartner; Niklas Pircher; Florian Schwarzhans; Anca Pantalon; Harminder Dua; Leopold Schmetterer
Journal:  Biomed Opt Express       Date:  2017-01-30       Impact factor: 3.732

Review 2.  Emerging Therapeutic Strategies for Limbal Stem Cell Deficiency.

Authors:  Ying Dong; Han Peng; Robert M Lavker
Journal:  J Ophthalmol       Date:  2018-06-27       Impact factor: 1.909

Review 3.  Simple limbal epithelial transplantation (SLET): Review of indications, surgical technique, mechanism, outcomes, limitations, and impact.

Authors:  Swapna S Shanbhag; Chaitali N Patel; Ritin Goyal; Pragnya R Donthineni; Vivek Singh; Sayan Basu
Journal:  Indian J Ophthalmol       Date:  2019-08       Impact factor: 1.848

Review 4.  Simple limbal epithelial transplantation: Current status and future perspectives.

Authors:  Catherine J Jackson; Inger T Myklebust Ernø; Håkon Ringstad; Kim A Tønseth; Darlene A Dartt; Tor P Utheim
Journal:  Stem Cells Transl Med       Date:  2019-12-04       Impact factor: 6.940

5.  Case Report: Allogenic Simple Limbal Epithelial Transplantation From a Human Leukocyte Antigen-Matched Living Related Donor to Treat Bilateral Corneal Chemical Burns Post Laser-Assisted in situ Keratomileusis.

Authors:  Yuh-Shin Chang; Tsung-Yueh Chan; Ren-Long Jan; Sung-Huei Tseng
Journal:  Front Med (Lausanne)       Date:  2022-02-25

Review 6.  Potential of mesenchymal stem cells as topical immunomodulatory cell therapies for ocular surface inflammatory disorders.

Authors:  Lydia J Beeken; Darren S J Ting; Laura E Sidney
Journal:  Stem Cells Transl Med       Date:  2020-09-08       Impact factor: 6.940

Review 7.  Economic, clinical and social impact of simple limbal epithelial transplantation for limbal stem cell deficiency.

Authors:  Praveen Thokala; Aastha Singh; Vijay Kumar Singh; Varsha M Rathi; Sayan Basu; Vivek Singh; Sheila MacNeil; Virender Singh Sangwan
Journal:  Br J Ophthalmol       Date:  2021-03-09       Impact factor: 5.908

  7 in total

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