Literature DB >> 27504300

Idiopathic Fatal Pancytopenia: A Case Report.

Hema Goyal1, Vijai Tilak2.   

Abstract

Pancytopenia is defined as decrease in red blood cells, white blood cells and platelets. Many disease processes involve the bone marrow primarily or secondarily resulting in pancytopenia. A 55-year-old male presented with generalized body weakness and few episodes of malena for last one year. Physical and systemic examination was unremarkable. CBC report revealed pancytopenia. Other haematological parameters were within normal limit. Stool for occult blood was positive. USG and CECT abdomen showed no abnormality. The patient was evaluated for any evidence of malignancy but no clue was found. Bone marrow examination was done as patient was having pancytopenia. Bone marrow smears, clot sections and bone marrow biopsy was normal. Immunohistochemistry and cytogenetics study was unremarkable. Patient was admitted in hospital for 1 month and his condition rapidly deteriorated. The cause of pancytopenia remained unexplained and therefore it was named as Idiopathic fatal pancytopenia. "Idiopathic Fatal Pancytopenia (IFP)" is an emerging new entity with a grave prognosis. We wish to sensitize the medical community and the scientists to this rapidly fatal condition.

Entities:  

Keywords:  Cytogenetics; Idiopathic cytopenia of undetermined significance (ICUS); Immunohistochemistry

Year:  2016        PMID: 27504300      PMCID: PMC4963660          DOI: 10.7860/JCDR/2016/19230.7996

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  7 in total

1.  Distinguishing myelodysplastic syndromes (MDS) from idiopathic cytopenia of undetermined significance (ICUS): HUMARA unravels clonality in a subgroup of patients.

Authors:  T Schroeder; L Ruf; A Bernhardt; B Hildebrandt; M Aivado; C Aul; N Gattermann; R Haas; U Germing
Journal:  Ann Oncol       Date:  2010-05-03       Impact factor: 32.976

Review 2.  Definitions and standards in the diagnosis and treatment of the myelodysplastic syndromes: Consensus statements and report from a working conference.

Authors:  Peter Valent; Hans-Peter Horny; John M Bennett; Christa Fonatsch; Ulrich Germing; Peter Greenberg; Torsten Haferlach; Detlef Haase; Hans-Jochen Kolb; Otto Krieger; Michael Loken; Arjan van de Loosdrecht; Kiyoyuki Ogata; Alberto Orfao; Michael Pfeilstöcker; Björn Rüter; Wolfgang R Sperr; Reinhard Stauder; Denise A Wells
Journal:  Leuk Res       Date:  2007-01-25       Impact factor: 3.156

Review 3.  Idiopathic cytopenia of undetermined significance (ICUS) and idiopathic dysplasia of uncertain significance (IDUS), and their distinction from low risk MDS.

Authors:  Peter Valent; Barbara J Bain; John M Bennett; Friedrich Wimazal; Wolfgang R Sperr; Ghulam Mufti; Hans-Peter Horny
Journal:  Leuk Res       Date:  2011-09-13       Impact factor: 3.156

4.  MDS-associated somatic mutations and clonal hematopoiesis are common in idiopathic cytopenias of undetermined significance.

Authors:  Brian Kwok; Jeff M Hall; John S Witte; Yin Xu; Prashanti Reddy; Keming Lin; Rachel Flamholz; Bashar Dabbas; Aine Yung; Jenan Al-Hafidh; Emily Balmert; Christine Vaupel; Carlos El Hader; Matthew J McGinniss; Shareef A Nahas; Julie Kines; Rafael Bejar
Journal:  Blood       Date:  2015-10-01       Impact factor: 22.113

5.  Bone marrow examination in cases of pancytopenia.

Authors:  A Jha; G Sayami; R C Adhikari; A D Panta; R Jha
Journal:  JNMA J Nepal Med Assoc       Date:  2008 Jan-Mar       Impact factor: 0.406

6.  Idiopathic cytopenia of undetermined significance (ICUS) versus low risk MDS: the diagnostic interface.

Authors:  Friedrich Wimazal; Christa Fonatsch; Renate Thalhammer; Ilse Schwarzinger; Leonhard Müllauer; Wolfgang R Sperr; John M Bennett; Peter Valent
Journal:  Leuk Res       Date:  2007-05-16       Impact factor: 3.156

7.  Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis.

Authors:  Lambert Busque; Jay P Patel; Maria E Figueroa; Aparna Vasanthakumar; Sylvie Provost; Zineb Hamilou; Luigina Mollica; Juan Li; Agnes Viale; Adriana Heguy; Maryam Hassimi; Nicholas Socci; Parva K Bhatt; Mithat Gonen; Christopher E Mason; Ari Melnick; Lucy A Godley; Cameron W Brennan; Omar Abdel-Wahab; Ross L Levine
Journal:  Nat Genet       Date:  2012-09-23       Impact factor: 38.330

  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.