| Literature DB >> 27502534 |
N E Sharanova1, N V Kirbaeva2, I Yu Toropygin3, E V Khryapova3, E V Koplik4, C Kh Soto2, S S Pertsov4, A V Vasiliev2.
Abstract
We compared proteome profiles of selected brain areas (cortex, amygdala, hippocampus, and reticular formation) and measured cathepsins B and D activity in liver lysosomal fraction in rats with different behavioral activity under conditions of emotional stress. In passive rats, the expression of some proteins in various brain regions was changed and baseline cathepsin B activity was higher than in active animals. Taken together, the results attest to differences in the adaptive response formation in rats, depending on behavioral features.Entities:
Keywords: brain; cathepsin B; cathepsin D; emotional stress; proteomics
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Year: 2016 PMID： 27502534 DOI： 10.1007/s10517-016-3413-3
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804