Stefan Reichert1, Susanne Schulz2, Ann-Christin Benten2, Andrea Lutze2,3, Tim Seifert2,3, Manuela Schlitt3, Karl Werdan3, Britt Hofmann4, Andreas Wienke5, Hans-Günter Schaller2, Axel Schlitt3,6. 1. Department of Operative Dentistry and Periodontology, Martin Luther University Halle-Wittenberg, Halle, Germany. stefan.reichert@uk-halle.de. 2. Department of Operative Dentistry and Periodontology, Martin Luther University Halle-Wittenberg, Halle, Germany. 3. Department of Internal Medicine III, Heart Centre of the University Clinics Halle (Saale), Martin Luther University Halle-Wittenberg, Halle, Germany. 4. Department of Cardiothoracic Surgery, Heart Centre of the University Clinics Halle (Saale), Martin Luther University Halle-Wittenberg, Halle, Germany. 5. Institute for Medical Epidemiology, Biostatistics, and Informatics, Martin Luther University Halle-Wittenberg, Halle, Germany. 6. Department of Cardiology, Paracelsus Harz-Clinic Bad Suderode, Halle, Germany.
Abstract
AIM: We wanted to investigate whether periodontal conditions and/or oral care habits are associated with new cardiovascular events among patients with coronary vascular disease (CVD). MATERIALS AND METHODS: In this longitudinal cohort study, 1002 inpatients with CVD were included. They were examined regarding prevalence of severe periodontitis, bleeding upon probing (BOP), number of missing teeth and oral care habits. The combined endpoint was defined as myocardial infarction, stroke/transient ischaemic attack, cardiovascular death and death caused by stroke. Survival analyses were carried out after a 3-year follow-up period. Hazard ratios (HRs) were adjusted for known cardiac risk factors using Cox regression. RESULTS: Nine hundred and fifty-three patients completed the 3-year follow-up. The overall incidence of the combined endpoint was 16.4%. Significant HRs for BOP (HR = 2, 95% CI: 1.2-3.3), severe tooth loss (HR = 1.8, 95% CI: 1.3-2.5), brushing teeth more than once a day (HR = 0.6, 95% CI: 0.5-1.0) and use of floss/inter-dental brushes (HR = 0.5, 95% CI: 0.3-0.9) were evaluated only in univariate but not in multivariate survival analyses. Patients with severe periodontitis achieved the combined endpoint more often (18.9% versus 14.2%), but the result was not statistically significant after both univariate and multivariate survival analyses. CONCLUSIONS: Periodontal conditions and oral care habits are not independent indicators for further adverse events in patients with CVD.
AIM: We wanted to investigate whether periodontal conditions and/or oral care habits are associated with new cardiovascular events among patients with coronary vascular disease (CVD). MATERIALS AND METHODS: In this longitudinal cohort study, 1002 inpatients with CVD were included. They were examined regarding prevalence of severe periodontitis, bleeding upon probing (BOP), number of missing teeth and oral care habits. The combined endpoint was defined as myocardial infarction, stroke/transient ischaemic attack, cardiovascular death and death caused by stroke. Survival analyses were carried out after a 3-year follow-up period. Hazard ratios (HRs) were adjusted for known cardiac risk factors using Cox regression. RESULTS: Nine hundred and fifty-three patients completed the 3-year follow-up. The overall incidence of the combined endpoint was 16.4%. Significant HRs for BOP (HR = 2, 95% CI: 1.2-3.3), severe tooth loss (HR = 1.8, 95% CI: 1.3-2.5), brushing teeth more than once a day (HR = 0.6, 95% CI: 0.5-1.0) and use of floss/inter-dental brushes (HR = 0.5, 95% CI: 0.3-0.9) were evaluated only in univariate but not in multivariate survival analyses. Patients with severe periodontitis achieved the combined endpoint more often (18.9% versus 14.2%), but the result was not statistically significant after both univariate and multivariate survival analyses. CONCLUSIONS: Periodontal conditions and oral care habits are not independent indicators for further adverse events in patients with CVD.
Authors: Mariano Sanz; Alvaro Marco Del Castillo; Søren Jepsen; Jose R Gonzalez-Juanatey; Francesco D'Aiuto; Philippe Bouchard; Iain Chapple; Thomas Dietrich; Israel Gotsman; Filippo Graziani; David Herrera; Bruno Loos; Phoebus Madianos; Jean-Baptiste Michel; Pablo Perel; Burkert Pieske; Lior Shapira; Michael Shechter; Maurizio Tonetti; Charalambos Vlachopoulos; Gernot Wimmer Journal: J Clin Periodontol Date: 2020-02-03 Impact factor: 8.728
Authors: Stefan Reichert; Britt Hofmann; Michael Kohnert; Alexander Navarrete Santos; Lisa Friebe; Julia Grollmitz; Hans-Günter Schaller; Susanne Schulz Journal: J Clin Med Date: 2022-07-15 Impact factor: 4.964
Authors: M Sanz; A Marco Del Castillo; S Jepsen; J R Gonzalez-Juanatey; F D'Aiuto; P Bouchard; I Chapple; T Dietrich; I Gotsman; F Graziani; D Herrera; B Loos; P Madianos; J B Michel; P Perel; B Pieske; L Shapira; M Shechter; M Tonetti; C Vlachopoulos; G Wimmer Journal: Glob Heart Date: 2020-02-03