Daniel Papoti1, Cecil Chern-Chyi Yen1, Chia-Chun Hung1,2, Jennifer Ciuchta1, David A Leopold2, Afonso C Silva1. 1. Cerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. 2. Section on Cognitive Neurophysiology and Imaging, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Abstract
PURPOSE: The common marmoset (Callithrix jacchus) is a New World primate of increasing interest to neuroscience and in translational brain research. The present work describes the design and implementation of individualized 8-channel receive-only radiofrequency (RF) coil arrays that provide whole-brain coverage and allow anatomical and functional MRI experiments in conscious, awake marmosets. METHODS: The coil arrays were designed with their elements embedded inside individualized restraint helmets. The size, geometry, and arrangement of the coil elements were optimized to allow whole-brain coverage. Coil-to-coil decoupling was achieved by a combination of geometric decoupling and low input impedance preamplifiers. The performance of the embedded arrays was compared against that of one 8-channel receive-only array built to fit the external surface of the helmets. RESULTS: Three individualized helmets with embedded coil arrays were built for three marmosets. Whole-brain coverage was achieved with high sensitivity extending over the entire cortex. Visual stimulation of conscious awake marmosets elicited robust BOLD fMRI responses in both primary and higher order visual areas of the occipitotemporal cortex. CONCLUSION: The high sensitivity provided by embedded receive-only coil arrays allows both anatomical and functional MRI data to be obtained with high spatial resolution in conscious, awake marmosets. Magn Reson Med 78:387-398, 2017.
PURPOSE: The common marmoset (Callithrix jacchus) is a New World primate of increasing interest to neuroscience and in translational brain research. The present work describes the design and implementation of individualized 8-channel receive-only radiofrequency (RF) coil arrays that provide whole-brain coverage and allow anatomical and functional MRI experiments in conscious, awake marmosets. METHODS: The coil arrays were designed with their elements embedded inside individualized restraint helmets. The size, geometry, and arrangement of the coil elements were optimized to allow whole-brain coverage. Coil-to-coil decoupling was achieved by a combination of geometric decoupling and low input impedance preamplifiers. The performance of the embedded arrays was compared against that of one 8-channel receive-only array built to fit the external surface of the helmets. RESULTS: Three individualized helmets with embedded coil arrays were built for three marmosets. Whole-brain coverage was achieved with high sensitivity extending over the entire cortex. Visual stimulation of conscious awake marmosets elicited robust BOLD fMRI responses in both primary and higher order visual areas of the occipitotemporal cortex. CONCLUSION: The high sensitivity provided by embedded receive-only coil arrays allows both anatomical and functional MRI data to be obtained with high spatial resolution in conscious, awake marmosets. Magn Reson Med 78:387-398, 2017.
Authors: Chia-Chun Hung; Cecil C Yen; Jennifer L Ciuchta; Daniel Papoti; Nicholas A Bock; David A Leopold; Afonso C Silva Journal: Neuroimage Date: 2015-07-03 Impact factor: 6.556
Authors: Chia-Chun Hung; Cecil C Yen; Jennifer L Ciuchta; Daniel Papoti; Nicholas A Bock; David A Leopold; Afonso C Silva Journal: J Neurosci Date: 2015-01-21 Impact factor: 6.167
Authors: David J Schaeffer; L Martyn Klassen; Yuki Hori; Xiaoguang Tian; Diego Szczupak; Cecil Chern-Chyi Yen; Justine C Cléry; Kyle M Gilbert; Joseph S Gati; Ravi S Menon; CiRong Liu; Stefan Everling; Afonso C Silva Journal: Neuroimage Date: 2022-02-22 Impact factor: 7.400
Authors: Maxime Donadieu; Hannah Kelly; Diego Szczupak; Jing-Ping Lin; Yeajin Song; Cecil C C Yen; Frank Q Ye; Hadar Kolb; Joseph R Guy; Erin S Beck; Steven Jacobson; Afonso C Silva; Pascal Sati; Daniel S Reich Journal: Cereb Cortex Date: 2021-01-01 Impact factor: 5.357
Authors: Emily C Leibovitch; Breanna Caruso; Seung Kwon Ha; Matthew K Schindler; Nathanael J Lee; Nicholas J Luciano; Bridgette J Billioux; Joseph R Guy; Cecil Yen; Pascal Sati; Afonso C Silva; Daniel S Reich; Steven Jacobson Journal: Proc Natl Acad Sci U S A Date: 2018-10-15 Impact factor: 11.205
Authors: Cirong Liu; Cecil Chern-Chyi Yen; Diego Szczupak; Frank Q Ye; David A Leopold; Afonso C Silva Journal: Nat Commun Date: 2019-04-29 Impact factor: 14.919
Authors: Kyle M Gilbert; Justine C Cléry; Joseph S Gati; Yuki Hori; Kevin D Johnston; Alexander Mashkovtsev; Janahan Selvanayagam; Peter Zeman; Ravi S Menon; David J Schaeffer; Stefan Everling Journal: Nat Commun Date: 2021-11-16 Impact factor: 14.919