| Literature DB >> 27501138 |
Akanksha Jain1, Anupam Mathur2, Usha Pandey1, Jyotsna Bhatt1, Archana Mukherjee1, Ramu Ram1, Haladhar Dev Sarma3, Ashutosh Dash4.
Abstract
Present work evaluates the potential of a newly synthesized (68)Ga-NOTA-folic acid conjugate for PET imaging of tumors over-expressing folate receptors (FRs). NOTA-folic acid conjugate was synthesized and characterized. It was radiolabeled with (68)Ga in ≥ 95% radiolabeling yields. In vitro cell binding studies showed a maximum cell uptake of 1.7±0.4% per million KB cells which was completely blocked on addition of cold folic acid showing specificity towards the FRs. However, further studies in tumor xenografts are warranted in order to assess the potential of (68)Ga-folic acid complex for imaging tumors over-expressing FRs.Entities:
Keywords: Folate receptors; Folic acid; Gallium-68; NOTA-folic acid
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Year: 2016 PMID： 27501138 DOI： 10.1016/j.apradiso.2016.07.024
Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513