Stephen L Chan1,2,3, Anthony W H Chan1,4, Allen K C Chan1,5, Peiyong Jian1,5, Frankie Mo1,2, Charles M L Chan1,2, Kevin Mok6, Calvin Liu6, Charing C N Chong7, Anthony T C Chan1,2, Tony Mok1,2, Winnie Yeo1,2. 1. State Key Laboratory in Oncology of South China, Hong Kong, China. 2. Department of Clinical Oncology, Sir YK Pao Center for Cancer, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China. 3. Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China. 4. Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China. 5. Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, China. 6. Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. 7. Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Abstract
BACKGROUNDS & AIMS: A number of circulating inflammatory factors are implicated in the pathogenesis and prognostication of hepatocellular carcinoma (HCC). We aim to evaluate the prognostication of multiple serum inflammatory factors simultaneously and develop an objective inflammatory score for HCC. METHODS: A prospective cohort of 555 patients with HCC with paired serum samples was accrued from 2009 to 2012. The blood levels of conventional inflammatory markers, namely C-reactive protein (CRP), albumin, neutrophils, lymphocytes and platelet, were determined, and 41 other exploratory markers were measured by a multiplex assay. The prognostication and interaction of markers were determined by univariate and multivarite analyses. RESULTS: The cohort was randomly divided into training cohort (n=139) and validation cohort (n=416). There were no differences in baseline characteristics between the two cohorts. In the training cohort, independent prognostic factors for overall survival included CRP (hazard ratio [HR] 1.107; P=.003), albumin (HR 0.953; P=.032) and interleukin-8 (HR=5.816; P<.001). We have modified the existing inflammation-based index (IBI) by adding serum interleukin-8 level. The modified IBI could stratify patients into four groups with distinct overall survival (P<.001). The results were also validated in the validation cohort. When compared with IBI and other conventional inflammatory markers, the modified IBI had better prognostic performance with higher c-index and homogeneity likelihood ratio chi-square. CONCLUSIONS: Among the conventional and exploratory circulating inflammatory markers, higher CRP, lower albumin and higher interleukin-8 were independent prognosticators. By combining these factors, a simple and accurate inflammatory index could be constructed.
BACKGROUNDS & AIMS: A number of circulating inflammatory factors are implicated in the pathogenesis and prognostication of hepatocellular carcinoma (HCC). We aim to evaluate the prognostication of multiple serum inflammatory factors simultaneously and develop an objective inflammatory score for HCC. METHODS: A prospective cohort of 555 patients with HCC with paired serum samples was accrued from 2009 to 2012. The blood levels of conventional inflammatory markers, namely C-reactive protein (CRP), albumin, neutrophils, lymphocytes and platelet, were determined, and 41 other exploratory markers were measured by a multiplex assay. The prognostication and interaction of markers were determined by univariate and multivarite analyses. RESULTS: The cohort was randomly divided into training cohort (n=139) and validation cohort (n=416). There were no differences in baseline characteristics between the two cohorts. In the training cohort, independent prognostic factors for overall survival included CRP (hazard ratio [HR] 1.107; P=.003), albumin (HR 0.953; P=.032) and interleukin-8 (HR=5.816; P<.001). We have modified the existing inflammation-based index (IBI) by adding serum interleukin-8 level. The modified IBI could stratify patients into four groups with distinct overall survival (P<.001). The results were also validated in the validation cohort. When compared with IBI and other conventional inflammatory markers, the modified IBI had better prognostic performance with higher c-index and homogeneity likelihood ratio chi-square. CONCLUSIONS: Among the conventional and exploratory circulating inflammatory markers, higher CRP, lower albumin and higher interleukin-8 were independent prognosticators. By combining these factors, a simple and accurate inflammatory index could be constructed.
Authors: Hans Dieter Nischalke; Philipp Lutz; Eva Bartok; Benjamin Krämer; Bettina Langhans; Regina Frizler; Thomas Berg; Jochen Hampe; Stephan Buch; Christian Datz; Felix Stickel; Gunther Hartmann; Christian P Strassburg; Jacob Nattermann; Ulrich Spengler Journal: J Mol Med (Berl) Date: 2019-10-21 Impact factor: 4.599
Authors: Lorenza Rimassa; Robin Kate Kelley; Tim Meyer; Baek-Yeol Ryoo; Philippe Merle; Joong-Won Park; Jean-Frederic Blanc; Ho Yeong Lim; Albert Tran; Yi-Wah Chan; Paul McAdam; Evelyn Wang; Ann-Lii Cheng; Anthony B El-Khoueiry; Ghassan K Abou-Alfa Journal: Liver Cancer Date: 2021-12-03 Impact factor: 11.740
Authors: Jane Margetts; Laura F Ogle; Stephen L Chan; Anthony W H Chan; K C Allen Chan; David Jamieson; Catherine E Willoughby; Derek A Mann; Caroline L Wilson; Derek M Manas; Winnie Yeo; Helen L Reeves Journal: Br J Cancer Date: 2017-11-09 Impact factor: 7.640
Authors: Leung Li; Stephen L Chan; Frankie Mo; Edwin P Hui; Jane Koh; Allen K C Chan; Nelson L S Tang; Kit F Lee; Paul B S Lai; Simon C H Yu; Winnie Yeo Journal: Cancer Manag Res Date: 2019-04-04 Impact factor: 3.989