Literature DB >> 27501050

Ischemic post-conditioning attenuates acute lung injury induced by intestinal ischemia-reperfusion in mice: role of Nrf2.

Qing-Tao Meng1, Chen Cao2, Yang Wu1, Hui-Min Liu1, Wei Li1, Qian Sun1, Rong Chen1, Yong-Guang Xiao3, Ling-Hua Tang1, Ying Jiang1, Yan Leng1, Shao-Qing Lei1, Chris C Lee4, Devin M Barry4, Xiangdong Chen1,5, Zhong-Yuan Xia1.   

Abstract

Intestinal ischemic post-conditioning (IPo) protects against lung injury induced by intestinal ischemia-reperfusion (IIR) partly through promotion of expression and function of heme oxygenase-1 (HO-1). NF-E2-related factor-2 (Nrf2) is a key transcription factor that interacts with HO-1 and regulates antioxidant defense. However, the role of Nrf2 in IPo protection of IIR-induced pulmonary injury is not completely understood. Here we show that IPo significantly attenuated IIR-induced lung injury and suppressed oxidative stress and systemic inflammatory responses. IPo also increased the expression of both Nrf2 and HO-1. Consistently, the beneficial effects of IPo were abolished by ATRA and Brusatol, potent inhibitors of Nrf2. Moreover, the Nrf2 agonist t-BHQ showed similar activity as IPo. Taken together, our data suggest that Nrf2 activity, along with HO-1, plays an important role in the protective effects of IPo against IIR-induced acute lung injury.

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Year:  2016        PMID： 27501050     DOI： 10.1038/labinvest.2016.87

Source DB:  PubMed          Journal:  Lab Invest        ISSN： 0023-6837            Impact factor:   5.662


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