Literature DB >> 27498999

Association Between Presence of Virulence Genes and Antibiotic Resistance in Clinical Klebsiella Pneumoniae Isolates.

Safoura Derakhshan1, Shahin Najar Peerayeh2, Bita Bakhshi2.   

Abstract

OBJECTIVE: To investigate the presence of rmpA and wcaG virulence genes and Class 1, 2, and 3 integrons, and to evaluate a relationship between antibiotic resistance and virulence in Klebsiella pneumoniae
METHODS: We collected a total of 200 K. pneumoniae isolates from hospitals in Tehran, Iran. Antibiotic susceptibility was determined using the disk diffusion method. The extended-spectrum β-lactamase (ESBL) producers were detected using the combination disk method. We detected the rmpA and wcaG genes and class 1, 2, and 3 integrons via polymerase chain reaction (PCR). The χ2 test was used for statistical evaluation.
RESULTS: Of 200 isolates, 115 (57.5%) were ESBL producers; 74.0% carried the class 1 integron, and 1.0% carried the class 2 integron. The gene rmpA was detected in 7% of isolates and the gene wcaG in 23.5% of isolates. Integron-positive isolates showed a higher prevalence of wcaG compared with to integron-negative isolates (P <.05).
CONCLUSION: Our results showed a correlation between presence of virulence gene and antibiotic resistance in K. pneumoniae. © American Society for Clinical Pathology, 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  Klebsiella pneumoniae; antibiotic resistance; bacterial capsule; extended-spectrum beta-lactamase; integrons; virulence genes

Mesh：

Substances：

Year:  2016        PMID： 27498999     DOI： 10.1093/labmed/lmw030

Source DB:  PubMed          Journal:  Lab Med        ISSN： 0007-5027


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3.  Association between Presence of RmpA, MrkA and MrkD Genes and Antibiotic Resistance in Clinical Klebsiella pneumoniae Isolates from Hospitals in Tehran, Iran.

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