| Literature DB >> 27498604 |
Raffaella Bonecchi1, Cecilia Garlanda2, Alberto Mantovani3, Federica Riva4.
Abstract
IL-1R2 was the first decoy receptor to be described. Subsequently receptors which act as pure decoys or scavengers or trigger dampening of cytokine signaling have been described for cytokines and chemokines. Here we review the current understanding of the mode of action and significance in pathology of the chemokine atypical receptor ACKR2, the IL-1 decoy receptor IL-1R2 and the atypical IL-1 receptor family IL-1R8. Decoy and scavenger receptors with no or atypical signaling have emerged as a general strategy conserved in evolution to tune the action of cytokines, chemokines and growth factors.Entities:
Keywords: Atypical chemokine receptor; Chemokine; Innate immunity; Interleukin-1; Regulation of inflammation
Mesh:
Substances:
Year: 2016 PMID: 27498604 PMCID: PMC5414836 DOI: 10.1016/j.cyto.2016.06.023
Source DB: PubMed Journal: Cytokine ISSN: 1043-4666 Impact factor: 3.861