Etsuro Nanishi1, Takayuki Hoshina2, Hidetoshi Takada3, Masataka Ishimura4, Hisanori Nishio5, Takahiro Uehara6, Yumi Mizuno7, Shunji Hasegawa8, Shouichi Ohga9, Masayoshi Nagao10, Maiko Igarashi11, Shuhei Yajima12, Yoshio Kusumoto13, Noriko Onishi14, Yoji Sasahara15, Takahiro Yasumi16, Toshio Heike16, Toshiro Hara17. 1. Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: nanishi@pediatr.med.kyushu-u.ac.jp. 2. Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan. 3. Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Perinatal and Pediatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 4. Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 5. Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Center for the Study of Global Infection, Kyushu University Hospital, Fukuoka, Japan. 6. Department of Pediatrics, Kameda Medical Center, Kamogawa, Japan. 7. Department of Pediatric Infectious Disease, Fukuoka Children's Hospital, Fukuoka, Japan. 8. Department of Pediatrics, Graduate School of Medicine, Yamaguchi University, Ube, Japan. 9. Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Pediatrics, Graduate School of Medicine, Yamaguchi University, Ube, Japan. 10. Department of Pediatrics and Clinical Research, NHO Hokkaido Medical Center, Sapporo, Japan. 11. Department of Pediatrics, Saiseikai Kawaguchi General Hospital, Kawaguchi, Japan. 12. Department of Pediatrics, Hamamatsu Medical Center, Hamamatsu, Japan. 13. Department of Pediatrics, Osaka General Medical Center, Osaka, Japan. 14. Department of Pediatrics, Fujita General Hospital, Fukushima, Japan. 15. Department of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Japan. 16. Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan. 17. Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Fukuoka Children's Hospital, Fukuoka, Japan.
Abstract
OBJECTIVES: Patients with primary immunodeficiency diseases (PID) are highly susceptible to various microorganisms. However, no population-based studies have been performed among common viral pathogens, such as respiratory syncytial virus (RSV), rotavirus (RV), varicella-zoster virus (VZV) and influenza virus (IV). The objective of this study was to reveal the clinical burden of these four infections among PID patients in Japan. METHODS: We conducted a nationwide survey by sending questionnaires to 898 hospitals with pediatric departments throughout Japan. RESULTS: Nine hundred ten PID patients from 621 hospitals were registered (response rate: 69.2%). Fifty-four of the patients were hospitalized due to these viral infections. The durations of hospitalization due to RSV and RV infections differed significantly in the PID patients with and without cellular immunodeficiency (12.0 vs 6.5 days, p = 0.041; and 14.0 vs 6.0 days, p = 0.031, respectively). There was no significant difference in the duration of hospitalization in PID patients with and without cellular immunodeficiency who were hospitalized with IV infections (7.3 vs 6.1 days, p = 0.53). CONCLUSIONS: Special attention should be paid to PID patients with compromised cellular immunity who present with RSV and RV infection due to their high risk for severe disease.
OBJECTIVES:Patients with primary immunodeficiency diseases (PID) are highly susceptible to various microorganisms. However, no population-based studies have been performed among common viral pathogens, such as respiratory syncytial virus (RSV), rotavirus (RV), varicella-zoster virus (VZV) and influenza virus (IV). The objective of this study was to reveal the clinical burden of these four infections among PID patients in Japan. METHODS: We conducted a nationwide survey by sending questionnaires to 898 hospitals with pediatric departments throughout Japan. RESULTS: Nine hundred ten PID patients from 621 hospitals were registered (response rate: 69.2%). Fifty-four of the patients were hospitalized due to these viral infections. The durations of hospitalization due to RSV and RV infections differed significantly in the PID patients with and without cellular immunodeficiency (12.0 vs 6.5 days, p = 0.041; and 14.0 vs 6.0 days, p = 0.031, respectively). There was no significant difference in the duration of hospitalization in PID patients with and without cellular immunodeficiency who were hospitalized with IV infections (7.3 vs 6.1 days, p = 0.53). CONCLUSIONS: Special attention should be paid to PID patients with compromised cellular immunity who present with RSV and RV infection due to their high risk for severe disease.
Authors: Gemma E Hartley; Emily S J Edwards; Julian J Bosco; Samar Ojaimi; Robert G Stirling; Paul U Cameron; Katie Flanagan; Magdalena Plebanski; Philip Mark Hogarth; Robyn E O'Hehir; Menno C van Zelm Journal: Clin Transl Immunology Date: 2020-10-16