Robert Chuter1, Robin Prestwich2, David Bird3, Andrew Scarsbrook4, Jonathan Sykes5, Daniel Wilson3, Richard Speight3. 1. Medical Physics and Engineering, Bexley Wing, St. James's University Hospital, Leeds Teaching Hospitals Trust, United Kingdom; Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, United Kingdom. Electronic address: Robert.Chuter@christie.nhs.uk. 2. Clinical Oncology, Bexley Wing, St. James's University Hospital, Leeds Teaching Hospitals Trust, United Kingdom. 3. Medical Physics and Engineering, Bexley Wing, St. James's University Hospital, Leeds Teaching Hospitals Trust, United Kingdom. 4. Radiology and Nuclear Medicine, Bexley Wing, St. James's University Hospital, Leeds Teaching Hospitals Trust, United Kingdom. 5. Radiation Oncology, Blacktown Hospital, Australia.
Abstract
BACKGROUND AND PURPOSE: To assess the accuracy of gross tumour volume (GTV) delineation for head and neck squamous cell carcinoma (HNSCC) using a diagnostic position MRI (MRI-D) deformably registered to the planning CT (pCT), by comparison with a dedicated planning position MRI (MRI-RT). MATERIAL AND METHODS: Fourteen patients with HNSCC underwent a T1-weighted MRI-D and MRI-RT. A reference GTV was defined as that delineated on MRI-RT rigidly registered to pCT. GTVs were delineated on: MRI-D and then registered to pCT by deformable image registration over the whole image (DIR-whole); MRI-D and then registered to pCT with rigid registration over a region of interest defined as GTV+3cm (Rigid-ROI); and on the pCT alone. These were compared using positional metrics to the reference. RESULTS: GTVs delineated on MRI-D followed by DIR-whole were significantly more accurate than those delineated on CT alone. The mean Dice Similarity Coefficient was 0.6 and 0.72 for pCT and DIR-whole respectively. Use of MRI-D with Rigid-ROI provided no advantage over CT-only delineation. CONCLUSIONS: Contouring on MRI-RT rigidly registered to pCT should be considered as the gold standard for HNSCC. In radiotherapy centres lacking a dedicated MRI-RT, the use of an MRI-D with DIR-whole offers a significant advantage for the accuracy of GTV delineation over contouring on pCT alone. Crown
BACKGROUND AND PURPOSE: To assess the accuracy of gross tumour volume (GTV) delineation for head and neck squamous cell carcinoma (HNSCC) using a diagnostic position MRI (MRI-D) deformably registered to the planning CT (pCT), by comparison with a dedicated planning position MRI (MRI-RT). MATERIAL AND METHODS: Fourteen patients with HNSCC underwent a T1-weighted MRI-D and MRI-RT. A reference GTV was defined as that delineated on MRI-RT rigidly registered to pCT. GTVs were delineated on: MRI-D and then registered to pCT by deformable image registration over the whole image (DIR-whole); MRI-D and then registered to pCT with rigid registration over a region of interest defined as GTV+3cm (Rigid-ROI); and on the pCT alone. These were compared using positional metrics to the reference. RESULTS: GTVs delineated on MRI-D followed by DIR-whole were significantly more accurate than those delineated on CT alone. The mean Dice Similarity Coefficient was 0.6 and 0.72 for pCT and DIR-whole respectively. Use of MRI-D with Rigid-ROI provided no advantage over CT-only delineation. CONCLUSIONS: Contouring on MRI-RT rigidly registered to pCT should be considered as the gold standard for HNSCC. In radiotherapy centres lacking a dedicated MRI-RT, the use of an MRI-D with DIR-whole offers a significant advantage for the accuracy of GTV delineation over contouring on pCT alone. Crown
Authors: Elizabeth M McKenzie; Anand Santhanam; Dan Ruan; Daniel O'Connor; Minsong Cao; Ke Sheng Journal: Med Phys Date: 2020-01-02 Impact factor: 4.071
Authors: Hannah Bainbridge; Ahmed Salem; Rob H N Tijssen; Michael Dubec; Andreas Wetscherek; Corinne Van Es; Jose Belderbos; Corinne Faivre-Finn; Fiona McDonald Journal: Transl Lung Cancer Res Date: 2017-12
Authors: Haylea Richardson; Mahesh Kumar; Minh Thi Tieu; Joel Parker; Jason A Dowling; Jameen Arm; Leah Best; Peter B Greer; Matthew Clapham; Christopher Oldmeadow; Laura O'Connor; Chris Wratten Journal: J Med Radiat Sci Date: 2021-10-22