Qiang Zeng1, Sheng-Yong Dong2, Man-Liu Wang3, Jin-Ming Li2, Chong-Lei Ren4, Chang-Qing Gao5. 1. Health Management Institute, Chinese PLA General Hospital, Beijing 100853, China. Electronic address: zq301@126.com. 2. Healthcare Department, Agency for Offices Administration of PLA, Beijing 100034, China. 3. Center of Biomedical Analysis, Tsinghua University, Beijing 100084, China. 4. Department of Cardiovascular Surgery, Chinese PLA General Hospital, Beijing 100853, China. 5. Department of Cardiovascular Surgery, Chinese PLA General Hospital, Beijing 100853, China. Electronic address: gaochq301@yahoo.com.
Abstract
OBJECTIVE: To investigate associations of novel cardiovascular markers with obesity in a general population. METHODS: A total of 9361 individuals without diabetes or cardiovascular disease were studied between 2009 and 2012 in China. High-sensitivity cardiac troponin T (hs-cTnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), brachial-ankle pulse wave velocity (baPWV), pulse pressure, and central systolic blood pressure (cSBP) were assessed according to body mass index (BMI) levels and different BMI/metabolic syndrome (MetS) combinations. RESULTS: 'Levels of hs-cTnT, baPWV, pulse pressure, and cSBP increased across BMI levels. Obesity was positively associated with these markers in multivariate models (P<0.05 for all). When stratified by MetS, these associations remained significant in the non-MetS group, and compared with normal weight participants, the obese participants had 1.87 (95% confidence interval: 1.48, 2.36), 1.27 (1.02, 1.57), 1.89 (1.39, 2.57), and 2.71 (2.11, 3.47) fold risks for having elevated hs-cTnT, baPWV, pulse pressure, and cSBP, respectively, and had 1.61 (1.26, 2.05), 1.75 (1.27, 2.42), 2.45 (1.46, 4.11), and 3.14 (2.13, 4.62) fold risks for having 1, 2, 3, and 4 elevated cardiovascular markers, respectively; while no relationship was observed between obesity and these novel markers in the MetS group, after multivariate adjustment. These results were unchanged when using a waist-hip ratio, body fat per cent, and visceral adiposity index to redefine obesity. CONCLUSIONS: Obesity was positively associated with novel cardiovascular markers (except NT-proBNP) in participants without MetS rather than in participants with MetS. Obese participants without MetS also had higher odds of having more number of elevated cardiovascular markers.
OBJECTIVE: To investigate associations of novel cardiovascular markers with obesity in a general population. METHODS: A total of 9361 individuals without diabetes or cardiovascular disease were studied between 2009 and 2012 in China. High-sensitivity cardiac troponin T (hs-cTnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), brachial-ankle pulse wave velocity (baPWV), pulse pressure, and central systolic blood pressure (cSBP) were assessed according to body mass index (BMI) levels and different BMI/metabolic syndrome (MetS) combinations. RESULTS: 'Levels of hs-cTnT, baPWV, pulse pressure, and cSBP increased across BMI levels. Obesity was positively associated with these markers in multivariate models (P<0.05 for all). When stratified by MetS, these associations remained significant in the non-MetS group, and compared with normal weight participants, the obeseparticipants had 1.87 (95% confidence interval: 1.48, 2.36), 1.27 (1.02, 1.57), 1.89 (1.39, 2.57), and 2.71 (2.11, 3.47) fold risks for having elevated hs-cTnT, baPWV, pulse pressure, and cSBP, respectively, and had 1.61 (1.26, 2.05), 1.75 (1.27, 2.42), 2.45 (1.46, 4.11), and 3.14 (2.13, 4.62) fold risks for having 1, 2, 3, and 4 elevated cardiovascular markers, respectively; while no relationship was observed between obesity and these novel markers in the MetS group, after multivariate adjustment. These results were unchanged when using a waist-hip ratio, body fat per cent, and visceral adiposity index to redefine obesity. CONCLUSIONS:Obesity was positively associated with novel cardiovascular markers (except NT-proBNP) in participants without MetS rather than in participants with MetS. Obeseparticipants without MetS also had higher odds of having more number of elevated cardiovascular markers.
Authors: Yashashwi Pokharel; Wensheng Sun; Dennis T Villareal; Elizabeth Selvin; Salim S Virani; Chiadi E Ndumele; Ron C Hoogeveen; Josef Coresh; Eric Boerwinkle; Kenneth R Butler; Scott D Solomon; James S Pankow; Biykem Bozkurt; Christie M Ballantyne; Vijay Nambi Journal: Eur J Prev Cardiol Date: 2016-12-12 Impact factor: 7.804
Authors: Paweł Krzesiński; Wiesław Piechota; Katarzyna Piotrowicz; Grzegorz Gielerak; Agnieszka Woźniak-Kosek Journal: Cardiol Res Pract Date: 2019-12-18 Impact factor: 1.866