Literature DB >> 27497223

Projection-Specific Dynamic Regulation of Inhibition in Amygdala Micro-Circuits.

Elisabeth Vogel1, Sabine Krabbe2, Jan Gründemann2, Jaclyn I Wamsteeker Cusulin2, Andreas Lüthi3.   

Abstract

Cannabinoid receptor type 1 (CB1R)-expressing CCK interneurons are key regulators of cortical circuits. Here we report that retrograde endocannabinoid signaling and CB1R-mediated regulation of inhibitory synaptic transmission onto basal amygdala principal neurons strongly depend on principal neuron projection target. Projection-specific asymmetries in the regulation of local inhibitory micro-circuits may contribute to the selective activation of distinct amygdala output pathways during behavioral changes.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID: 27497223     DOI: 10.1016/j.neuron.2016.06.036

Source DB:  PubMed          Journal:  Neuron        ISSN: 0896-6273            Impact factor:   17.173


  23 in total

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