Literature DB >> 27494666

ADARs Edit MicroRNAs to Promote Leukemic Stem Cell Activity.

Wen Cai Zhang1, Frank J Slack2.   

Abstract

Leukemic stem cells (LSCs) drive progression of chronic myeloid leukemia (CML) and tyrosine kinase inhibitor resistance through poorly understood mechanisms. Now in Cell Stem Cell, Zipeto et al. (2016) show targeting the RNA editing enzyme ADAR1 restores expression of let-7 and efficiently kills LSCs, providing an innovative therapeutic target in CML.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 27494666     DOI： 10.1016/j.stem.2016.07.012

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  6 in total

Review 1.  Non-coding RNA networks in cancer.

Authors:  Eleni Anastasiadou; Leni S Jacob; Frank J Slack
Journal:  Nat Rev Cancer       Date:  2017-11-24       Impact factor: 60.716

2.  MicroRNA-21 guide and passenger strand regulation of adenylosuccinate lyase-mediated purine metabolism promotes transition to an EGFR-TKI-tolerant persister state.

Authors:  Nicholas Skiados; Fareesa Aftab; Wen Cai Zhang; Cerena Moreno; Luis Silva; Paul Joshua Anthony Corbilla; John M Asara; Aaron N Hata; Frank J Slack
Journal:  Cancer Gene Ther       Date:  2022-07-15       Impact factor: 5.854

3.  Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution.

Authors:  Qingfei Jiang; Jane Isquith; Luisa Ladel; Adam Mark; Frida Holm; Cayla Mason; Yudou He; Phoebe Mondala; Isabelle Oliver; Jessica Pham; Wenxue Ma; Eduardo Reynoso; Shawn Ali; Isabella Jamieson Morris; Raymond Diep; Chanond Nasamran; Guorong Xu; Roman Sasik; Sara Brin Rosenthal; Amanda Birmingham; Sanja Coso; Gabriel Pineda; Leslie Crews; Mary E Donohoe; J Craig Venter; Thomas Whisenant; Ruben A Mesa; Ludmil B Alexandrov; Kathleen M Fisch; Catriona Jamieson
Journal:  Cell Rep       Date:  2021-01-26       Impact factor: 9.423

4.  miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma.

Authors:  Wen Cai Zhang; Julie M Wells; Kin-Hoe Chow; He Huang; Min Yuan; Tanvi Saxena; Mary Ann Melnick; Katerina Politi; John M Asara; Daniel B Costa; Carol J Bult; Frank J Slack
Journal:  Nat Metab       Date:  2019-04-08

Review 5.  microRNAs Tune Oxidative Stress in Cancer Therapeutic Tolerance and Resistance.

Authors:  Wen Cai Zhang
Journal:  Int J Mol Sci       Date:  2019-12-03       Impact factor: 5.923

Review 6.  Non-Coding RNAs in Lung Tumor Initiation and Progression.

Authors:  Ruben Mercado Santos; Cerena Moreno; Wen Cai Zhang
Journal:  Int J Mol Sci       Date:  2020-04-16       Impact factor: 6.208
  6 in total

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