Literature DB >> 27494167

Synthesis, antimicrobial activity and advances in structure-activity relationships (SARs) of novel tri-substituted thiazole derivatives.

Guda Mallikarjuna Reddy1, Jarem Raul Garcia2, Vemulapati Hanuman Reddy3, Ageo Meier de Andrade4, Alexandre Camilo4, Renan Augusto Pontes Ribeiro4, Sergio Ricardo de Lazaro4.   

Abstract

Trisubstituted thiazoles were synthesized and studied for their antimicrobial activity and supported by theoretical calculations. In addition, MIC, MBC and MFC were also tested. Moreover, the present study was analyzed to scrutinize comprehensive structure-activity relationships. In fact, LUMO orbital energy and orbital orientation was reliable to explain their antibacterial and antifungal assay. Amongst the tested compounds, tri-methyl-substituted thiazole compound showed higher antimicrobial activity and low MIC value due to highest LUMO energy.
Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Antimicrobial; MBC/MFC; MIC; Simulation studies; Thiazoles

Mesh：

Substances：

Year:  2016        PMID： 27494167     DOI： 10.1016/j.ejmech.2016.07.062

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  7 in total

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  7 in total

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