Constance Xhaard1, Juan J Lence-Anta2, Yan Ren1, Françoise Borson-Chazot3, Geneviève Sassolas4, Claire Schvartz5, Marc Colonna6, Brigitte Lacour7, Arlette Danzon8, Michel Velten9, Enora Clero1, Stéphane Maillard1, Emilie Marrer10, Laurent Bailly11, Eugènia Mariné Barjoan11, Martin Schlumberger12, Jacques Orgiazzi13, Elisabeth Adjadj14, Celia M Pereda2, Silvia Turcios15, Milagros Velasco2, Mae Chappe2, Idalmis Infante2, Marlene Bustillo2, Anabel García2, Sirced Salazar2, Regla Rodriguez16, Mohamed Amine Benadjaoud1, Rosa M Ortiz2, Carole Rubino1, Florent de Vathaire1. 1. U1018, Centre d'Epidémiologie et de Santé des Populations (CESP), Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France; Institut Gustave Roussy, Villejuif, France; Université Paris-Saclay, Villejuif, France. 2. National Institute of Oncology and Radiobiology (INOR), Havana, Cuba. 3. Groupement Hospitalier Lyon-Est, Hospices Civils de Lyon, Fédération d'Endocrinologie, Bron, France; Rhône-Alpes Thyroid Cancer Registry, Cancer Research Center of Lyon (UMR INSERM 1052, CNRS 5286), RTH Laennec Faculty of Medicine, University of Lyon, Lyon, France. 4. Rhône-Alpes Thyroid Cancer Registry, Cancer Research Center of Lyon (UMR INSERM 1052, CNRS 5286), RTH Laennec Faculty of Medicine, University of Lyon, Lyon, France. 5. Thyroid Cancer Registry of Champagne-Ardennes, Institut Jean Godinot, Reims, France. 6. Cancer Registry of Isère, Meylan, France. 7. U1018, Centre d'Epidémiologie et de Santé des Populations (CESP), Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France; French National Registry of Childhood Solid Tumours, CHU, Nancy, France. 8. Cancer Registry of Doubs, EA 3181, Université de Franche-Comté, Besançon, France. 9. Cancer Registry of Bas-Rhin, EA 3430, Faculty of Medicine, University of Strasbourg, Strasbourg, France. 10. Cancer Registry of Haut-Rhin, Mulhouse Hospital, Mulhouse, France. 11. Public Health Department, University Hospital Nice, Nice, France. 12. Institut Gustave Roussy, Villejuif, France. 13. Department of Endocrinology, Hospices Civils de Lyon, Lyon, France. 14. U1018, Centre d'Epidémiologie et de Santé des Populations (CESP), Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France; Université Paris-Saclay, Villejuif, France. 15. National Institute of Endocrinology, Havana, Cuba. 16. Cuban Public Health Ministry, Havana, Cuba.
Abstract
PURPOSE: Physical activity has been hypothesized to influence cancer occurrence through several mechanisms. To date, its relation with thyroid cancer risk has been examined in relatively few studies. We pooled 2 case-control studies conducted in Cuba and Eastern France to assess the relationship between self-reported practice of recreational physical activity since childhood and thyroid cancer risk. METHODS: This pooled study included 1,008 cases of differentiated thyroid cancer (DTC) matched with 1,088 controls (age range 9-35 and 17-60 years in the French and Cuban studies, respectively). Risk factors associated with the practice of recreational physical activity were estimated using OR and 95% CI. Logistic regressions were stratified by age class, country, and gender and were adjusted for ethnic group, level of education, number of pregnancies for women, height, BMI, and smoking status. RESULTS: Overall, the risk of thyroid cancer was slightly reduced among subjects who reported recreational physical activity (OR = 0.8; 95% CI 0.5-1.0). The weekly frequency (i.e. h/week) seems to be more relevant than the duration (years). CONCLUSION: Long-term recreational physical activity, practiced since childhood, may reduce the DTC risk. However, the mechanisms whereby the DTC risk decreases are not yet entirely clear.
PURPOSE: Physical activity has been hypothesized to influence cancer occurrence through several mechanisms. To date, its relation with thyroid cancer risk has been examined in relatively few studies. We pooled 2 case-control studies conducted in Cuba and Eastern France to assess the relationship between self-reported practice of recreational physical activity since childhood and thyroid cancer risk. METHODS: This pooled study included 1,008 cases of differentiated thyroid cancer (DTC) matched with 1,088 controls (age range 9-35 and 17-60 years in the French and Cuban studies, respectively). Risk factors associated with the practice of recreational physical activity were estimated using OR and 95% CI. Logistic regressions were stratified by age class, country, and gender and were adjusted for ethnic group, level of education, number of pregnancies for women, height, BMI, and smoking status. RESULTS: Overall, the risk of thyroid cancer was slightly reduced among subjects who reported recreational physical activity (OR = 0.8; 95% CI 0.5-1.0). The weekly frequency (i.e. h/week) seems to be more relevant than the duration (years). CONCLUSION: Long-term recreational physical activity, practiced since childhood, may reduce the DTC risk. However, the mechanisms whereby the DTC risk decreases are not yet entirely clear.
Entities:
Keywords:
Pooled case-control study; Recreational physical activity; Risk factors; Thyroid cancer
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