Alexander S Pasciak1, Austin C Bourgeois2, Ben E Paxton3, Laurentia Nodit4, Patricia N Coan5, Dara Kraitchman6, Sandra S Stinnett7, Vijay M Patel4, Yingli Fu6, Joleen K Adams5, M Katherine Tolbert8, Cassie N Lux8, Aravind Arepally9, Yong C Bradley10. 1. Departments of Radiology, University of Tennessee Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, Tennessee; The Johns Hopkins University School of Medicine, Baltimore, MD 21205. Electronic address: alexander.pasciak@gmail.com. 2. Departments of Radiology, University of Tennessee Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, Tennessee; Department of Radiology, The Medical University of South Carolina, Charleston, South Carolina. 3. Interventional Radiology, Prescott Radiologists, Prescott, Arizona. 4. Pathology, University of Tennessee Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, Tennessee. 5. Office of Laboratory Animal Care, University of Tennessee, College of Veterinary Medicine, Knoxville, Tennessee. 6. Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD 21205. 7. Department of Biostatistics, Duke University Medical Center, Durham, North Carolina. 8. Department of Small Animal Clinical Sciences, University of Tennessee, College of Veterinary Medicine, Knoxville, Tennessee. 9. Piedmont Radiology, Atlanta, Georgia; Interventional Radiology, Vanderbilt School of Medicine, Nashville, Tennessee. 10. Departments of Radiology, University of Tennessee Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, Tennessee.
Abstract
PURPOSE: To evaluate feasibility of left gastric artery (LGA) yttrium-90 ((90)Y) radioembolization as potential treatment for obesity in a porcine model. MATERIALS AND METHODS: This study included 8 young female pigs (12-13 weeks, 21.8-28.1 kg). Six animals received infusions of (90)Y resin microspheres (46.3-105.1 MBq) into the main LGA and the gastric artery arising from the splenic artery. Animal weight and serum ghrelin were measured before treatment and weekly thereafter. Animals were euthanized 69-74 days after treatment, and histologic analyses of mucosal integrity and ghrelin immunoreactive cell density were performed. RESULTS: Superficial mucosal ulcerations < 3.0 cm(2) were noted in 5 of 6 treated animals. Ghrelin immunoreactive cell density was significantly lower in treated versus untreated animals in the stomach fundus (13.5 vs 34.8, P < .05) and stomach body (11.2 vs 19.8, P < .05). Treated animals gained less weight than untreated animals over the study duration (40.2 kg ± 5.4 vs 54.7 kg ± 6.5, P = .053). Average fundic parietal area (165 cm(2) vs 282 cm(2), P = .067) and average stomach weight (297.2 g vs 397.0 g, P = .067) were decreased in treated versus untreated animals. Trichrome staining revealed significantly more fibrosis in treatment animals compared with control animals (13.0 vs 8.6, P < .05). No significant differences were identified in plasma ghrelin concentrations (P = .24). CONCLUSIONS: LGA (90)Y radioembolization is promising as a potential treatment for obesity. A larger preclinical study is needed to evaluate the safety and efficacy of this procedure further.
PURPOSE: To evaluate feasibility of left gastric artery (LGA) yttrium-90 ((90)Y) radioembolization as potential treatment for obesity in a porcine model. MATERIALS AND METHODS: This study included 8 young female pigs (12-13 weeks, 21.8-28.1 kg). Six animals received infusions of (90)Y resin microspheres (46.3-105.1 MBq) into the main LGA and the gastric artery arising from the splenic artery. Animal weight and serum ghrelin were measured before treatment and weekly thereafter. Animals were euthanized 69-74 days after treatment, and histologic analyses of mucosal integrity and ghrelin immunoreactive cell density were performed. RESULTS: Superficial mucosal ulcerations < 3.0 cm(2) were noted in 5 of 6 treated animals. Ghrelin immunoreactive cell density was significantly lower in treated versus untreated animals in the stomach fundus (13.5 vs 34.8, P < .05) and stomach body (11.2 vs 19.8, P < .05). Treated animals gained less weight than untreated animals over the study duration (40.2 kg ± 5.4 vs 54.7 kg ± 6.5, P = .053). Average fundic parietal area (165 cm(2) vs 282 cm(2), P = .067) and average stomach weight (297.2 g vs 397.0 g, P = .067) were decreased in treated versus untreated animals. Trichrome staining revealed significantly more fibrosis in treatment animals compared with control animals (13.0 vs 8.6, P < .05). No significant differences were identified in plasma ghrelin concentrations (P = .24). CONCLUSIONS: LGA (90)Y radioembolization is promising as a potential treatment for obesity. A larger preclinical study is needed to evaluate the safety and efficacy of this procedure further.
Authors: David J Kim; Hari S Raman; Amber Salter; Raja Ramaswamy; Andrew J Gunn; Clifford R Weiss; Olaguoke Akinwande Journal: Diagn Interv Radiol Date: 2018 Mar-Apr Impact factor: 2.630
Authors: Clifford R Weiss; Yingli Fu; Cyrus Beh; Charles Hu; Dorota Kedziorek; Eun-Ji Shin; Robert A Anders; Aravind Arepally; Dara L Kraitchman Journal: J Vasc Interv Radiol Date: 2020-08-14 Impact factor: 3.464