Leena E Tuomisto1, Pinja Ilmarinen2, Onni Niemelä3, Jussi Haanpää4, Terhi Kankaanranta5, Hannu Kankaanranta6. 1. Department of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland. Electronic address: leena.tuomisto@epshp.fi. 2. Department of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland. 3. Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital and University of Tampere, Finland. 4. Department of Clinical Physiology, Seinäjoki Central Hospital, Seinäjoki, Finland. 5. Police University College, Tampere, Finland. 6. Department of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland; Department of Respiratory Medicine, University of Tampere, Tampere, Finland.
Abstract
RATIONALE: Long-term prognosis of adult-onset asthma is poorly known. OBJECTIVE: To evaluate 12-year prognosis of adult-onset asthma and the factors associated with disease prognosis. METHODS: Seinäjoki Adult-onset Asthma Study (SAAS) is a 12-year real-life single-center follow-up study of new-onset asthma diagnosed at adult age and treated in primary and specialized care. Remission was defined by no symptoms and no asthma medication use for 6 months. Asthma control was evaluated according to Global Initiative for Asthma 2010. Factors associated with current asthma control were analyzed by multinomial multivariate logistic regression. MAIN RESULTS: A total of 203 patients (79% of the baseline population) were followed for 12 years. Remission occurred in 6 (3%) patients. In 34% asthma was controlled, in 36% it was partially controlled and in 30% uncontrolled. Uncontrolled asthma was predicted by elevated body-mass index at baseline, smoking (pack-years) and current allergic or persistent rhinitis. Elevated blood eosinophils and good lung function (FEV1) at baseline protected from uncontrolled asthma. In contrast, gender, age at the onset or baseline symptoms (Airways Questionnaire 20) were not significant predictors of uncontrolled disease. CONCLUSIONS: During a 12-year follow-up, remission of adult-onset asthma was rare occurring in only 3% of patients. The majority of patients (66%) presented either with uncontrolled or partially controlled asthma. This study is registered at ClinicalTrials.gov with identifier number NCT02733016.
RATIONALE: Long-term prognosis of adult-onset asthma is poorly known. OBJECTIVE: To evaluate 12-year prognosis of adult-onset asthma and the factors associated with disease prognosis. METHODS: Seinäjoki Adult-onset Asthma Study (SAAS) is a 12-year real-life single-center follow-up study of new-onset asthma diagnosed at adult age and treated in primary and specialized care. Remission was defined by no symptoms and no asthma medication use for 6 months. Asthma control was evaluated according to Global Initiative for Asthma 2010. Factors associated with current asthma control were analyzed by multinomial multivariate logistic regression. MAIN RESULTS: A total of 203 patients (79% of the baseline population) were followed for 12 years. Remission occurred in 6 (3%) patients. In 34% asthma was controlled, in 36% it was partially controlled and in 30% uncontrolled. Uncontrolled asthma was predicted by elevated body-mass index at baseline, smoking (pack-years) and current allergic or persistent rhinitis. Elevated blood eosinophils and good lung function (FEV1) at baseline protected from uncontrolled asthma. In contrast, gender, age at the onset or baseline symptoms (Airways Questionnaire 20) were not significant predictors of uncontrolled disease. CONCLUSIONS: During a 12-year follow-up, remission of adult-onset asthma was rare occurring in only 3% of patients. The majority of patients (66%) presented either with uncontrolled or partially controlled asthma. This study is registered at ClinicalTrials.gov with identifier number NCT02733016.
Authors: Minna Tommola; Ha-Kyeong Won; Pinja Ilmarinen; Heewon Jung; Leena E Tuomisto; Lauri Lehtimäki; Onni Niemelä; Tae-Bum Kim; Hannu Kankaanranta Journal: Respir Res Date: 2020-07-13
Authors: Kjell Larsson; Hannu Kankaanranta; Christer Janson; Lauri Lehtimäki; Björn Ställberg; Anders Løkke; Kristian Høines; Klaus Roslind; Charlotte Suppli Ulrik Journal: NPJ Prim Care Respir Med Date: 2020-06-05 Impact factor: 2.871
Authors: Juho Loponen; Pinja Ilmarinen; Leena E Tuomisto; Onni Niemelä; Minna Tommola; Pentti Nieminen; Lauri Lehtimäki; Hannu Kankaanranta Journal: Eur Clin Respir J Date: 2018-10-24
Authors: Iida Vähätalo; Pinja Ilmarinen; Leena E Tuomisto; Minna Tommola; Onni Niemelä; Lauri Lehtimäki; Pentti Nieminen; Hannu Kankaanranta Journal: ERJ Open Res Date: 2020-03-23