Literature DB >> 27492250

Role of thrombospondin 1 in liver diseases.

Yanzhang Li1,2, Courtney P Turpin1, Shuxia Wang1.   

Abstract

Thrombospondin 1 (TSP1) is a matricellular glycoprotein that can be secreted by many cell types. Through binding to extracellular proteins and/or cell surface receptors, TSP1 modulates a variety of cellular functions. Since its discovery in 1971, TSP1 has been found to play important roles in multiple biological processes including angiogenesis, apoptosis, latent transforming growth factor-β activation, and immune regulation. Thrombospondin 1 is also involved in regulating many organ functions. However, the role of TSP1 in liver diseases has not been extensively addressed. In this review, we summarize the findings about the possible role that TSP1 plays in chronic liver diseases focusing on non-alcoholic fatty liver diseases, liver fibrosis, and hepatocellular carcinoma.
© 2016 The Japan Society of Hepatology.

Entities:  

Keywords:  NAFLD; TGF-β; TSP1; angiogenesis; liver cancer; liver fibrosis

Year:  2016        PMID： 27492250      PMCID： PMC5292098          DOI： 10.1111/hepr.12787

Source DB:  PubMed          Journal:  Hepatol Res        ISSN： 1386-6346            Impact factor:   4.288


  92 in total

Review 1.  Thrombospondins as matricellular modulators of cell function.

Authors:  P Bornstein
Journal:  J Clin Invest       Date:  2001-04       Impact factor: 14.808

Review 2.  Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology.

Authors:  J E Murphy-Ullrich; M Poczatek
Journal:  Cytokine Growth Factor Rev       Date:  2000 Mar-Jun       Impact factor: 7.638

3.  Expresson of vascular endothelial growth factor, its receptors (FLT-1, KDR) and TSP-1 related to microvessel density and patient outcome in vertical growth phase melanomas.

Authors:  O Straume; L A Akslen
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Review 4.  Integrin-associated protein (CD47) and its ligands.

Authors:  E J Brown; W A Frazier
Journal:  Trends Cell Biol       Date:  2001-03       Impact factor: 20.808

Review 5.  The cell biology of thrombospondin-1.

Authors:  H Chen; M E Herndon; J Lawler
Journal:  Matrix Biol       Date:  2000-12       Impact factor: 11.583

6.  Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1.

Authors:  B Jiménez; O V Volpert; S E Crawford; M Febbraio; R L Silverstein; N Bouck
Journal:  Nat Med       Date:  2000-01       Impact factor: 53.440

Review 7.  Repair in avascular tissues: fibrosis in the transparent structures of the eye and thrombospondin 1.

Authors:  P Hiscott; D Armstrong; M Batterbury; S Kaye
Journal:  Histol Histopathol       Date:  1999-10       Impact factor: 2.303

8.  Increased expression of transforming growth factor-beta1 and thrombospondin-1 in congenital hepatic fibrosis: possible role of the hepatic stellate cell.

Authors:  M El-Youssef; Y Mu; L Huang; V Stellmach; S E Crawford
Journal:  J Pediatr Gastroenterol Nutr       Date:  1999-04       Impact factor: 2.839

9.  Expression of thrombospondin-1 in pancreatic carcinoma: correlation with microvessel density.

Authors:  H U Kasper; M Ebert; P Malfertheiner; A Roessner; C J Kirkpatrick; H K Wolf
Journal:  Virchows Arch       Date:  2001-02       Impact factor: 4.064

Review 10.  The functions of thrombospondin-1 and-2.

Authors:  J Lawler
Journal:  Curr Opin Cell Biol       Date:  2000-10       Impact factor: 8.382
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  17 in total

1.  Thrombospondin-1 Exacerbates Acute Liver Failure and Hepatic Encephalopathy Pathology in Mice by Activating Transforming Growth Factor β1.

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2.  Human amniotic mesenchymal stem cells-derived IGFBP-3, DKK-3, and DKK-1 attenuate liver fibrosis through inhibiting hepatic stellate cell activation by blocking Wnt/β-catenin signaling pathway in mice.

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Journal:  Stem Cell Res Ther       Date:  2022-06-03       Impact factor: 8.079

3.  Altered expression of thrombospondin-1/-2 in the cortex and synaptophysin in the hippocampus after middle cerebral artery occlusion and reperfusion.

Authors:  Yu Wang; Wei Chen; Bin Hou; Yan Gao; Zhihui Li; Xu Li; Chenggang Zhang
Journal:  Int J Clin Exp Pathol       Date:  2018-07-01

4.  Laminin alpha-3 and thrombospondin-1 differently regulate the survival and differentiation of hepatocytes and hepatic stem cells from neonatal mice.

Authors:  Shuai Zhang; Heba E Sharaf Eldin; Wei-Li Gu; Tao-Sheng Li
Journal:  Am J Transl Res       Date:  2021-11-15       Impact factor: 4.060

5.  Platelet TGF-β1 deficiency decreases liver fibrosis in a mouse model of liver injury.

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Journal:  Blood Adv       Date:  2018-03-13

6.  Impact of glutathione peroxidase 4 on cell proliferation, angiogenesis and cytokine production in hepatocellular carcinoma.

Authors:  Nataliya Rohr-Udilova; Eva Bauer; Gerald Timelthaler; Robert Eferl; Klaus Stolze; Matthias Pinter; Martha Seif; Hubert Hayden; Thomas Reiberger; Rolf Schulte-Hermann; Markus Peck-Radosavljevic; Dagmar Stoiber; Michael Trauner
Journal:  Oncotarget       Date:  2018-01-22

7.  Latexin Inactivation Enhances Survival and Long-Term Engraftment of Hematopoietic Stem Cells and Expands the Entire Hematopoietic System in Mice.

Authors:  Yi Liu; Cuiping Zhang; Zhenyu Li; Chi Wang; Jianhang Jia; Tianyan Gao; Gerhard Hildebrandt; Daohong Zhou; Subbarao Bondada; Peng Ji; Daret St Clair; Jinze Liu; Changguo Zhan; Hartmut Geiger; Shuxia Wang; Ying Liang
Journal:  Stem Cell Reports       Date:  2017-03-16       Impact factor: 7.765

8.  Five genes may predict metastasis in non-small cell lung cancer using bioinformatics analysis.

Authors:  Ruiying Sun; Xia Meng; Wei Wang; Boxuan Liu; Xin Lv; Jingyan Yuan; Lizhong Zeng; Yang Chen; Bo Yuan; Shuanying Yang
Journal:  Oncol Lett       Date:  2019-06-19       Impact factor: 2.967

9.  rAj-Tspin, a novel recombinant peptide from Apostichopus japonicus, suppresses the proliferation, migration, and invasion of BEL-7402 cells via a mechanism associated with the ITGB1-FAK-AKT pathway.

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Journal:  Invest New Drugs       Date:  2020-09-28       Impact factor: 3.651

10.  Platelet Transforming Growth Factor-β1 Induces Liver Sinusoidal Endothelial Cells to Secrete Interleukin-6.

Authors:  Alexandre Balaphas; Jeremy Meyer; Remo Perozzo; Magali Zeisser-Labouebe; Sarah Berndt; Antoine Turzi; Pierre Fontana; Leonardo Scapozza; Carmen Gonelle-Gispert; Leo H Bühler
Journal:  Cells       Date:  2020-05-25       Impact factor: 6.600
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