Literature DB >> 27492004

[Pulmonary hypertension : What is new in therapy?].

N Sommer1, M Hecker2, K Tello3, M Richter2, C Liebetrau4, M A Weigand5, W Seeger2, A Ghofrani2, H Gall2.   

Abstract

Pulmonary hypertension (PH) comprises a group of pulmonary vascular diseases that are characterized by progressive exertional dyspnea and right heart insufficiency ultimately resulting in right heart decompensation. The classification is into five clinical subgroups that form the absolutely essential basis for decisions on the indications for different pharmacological and non-pharmacological forms of treatment. The guidelines were updated in 2015 and in addition to the hitherto existing pharmacological treatment options of phosphodiesterase type 5 inhibitors, endothelin receptor antagonists and prostacyclins, the soluble guanylate cyclase stimulator riociguat has now been incorporated for treatment of certain forms of PH. This article provides an overview of the new treatment recommendations in the current guidelines, e. g. for PH patients who are in intensive care units due to surgical interventions or progressive right heart insufficiency.

Entities:  

Keywords:  Endothelin receptor antagonists; IP receptor agonist; Phosphodiesterase type 5 inhibitors; Prostacyclin; Soluble guanylyl cyclase

Mesh:

Substances:

Year:  2016        PMID: 27492004     DOI: 10.1007/s00101-016-0207-y

Source DB:  PubMed          Journal:  Anaesthesist        ISSN: 0003-2417            Impact factor:   1.041


  32 in total

Review 1.  Effects of Exercise Training on Exercise Capacity in Pulmonary Arterial Hypertension: A Systematic Review of Clinical Trials.

Authors:  Abraham Samuel Babu; Ramachandran Padmakumar; Arun G Maiya; Aswini Kumar Mohapatra; R L Kamath
Journal:  Heart Lung Circ       Date:  2015-11-18       Impact factor: 2.975

2.  The prognostic impact of follow-up assessments in patients with idiopathic pulmonary arterial hypertension.

Authors:  N Nickel; H Golpon; M Greer; L Knudsen; K Olsson; V Westerkamp; T Welte; M M Hoeper
Journal:  Eur Respir J       Date:  2011-09-01       Impact factor: 16.671

Review 3.  Chronic thromboembolic pulmonary hypertension.

Authors:  Karen M Olsson; Bernhard Meyer; Jan Hinrichs; Jens Vogel-Claussen; Marius M Hoeper; Serghei Cebotari
Journal:  Dtsch Arztebl Int       Date:  2014-12-12       Impact factor: 5.594

4.  Riociguat for the treatment of pulmonary arterial hypertension.

Authors:  Hossein-Ardeschir Ghofrani; Nazzareno Galiè; Friedrich Grimminger; Ekkehard Grünig; Marc Humbert; Zhi-Cheng Jing; Anne M Keogh; David Langleben; Michael Ochan Kilama; Arno Fritsch; Dieter Neuser; Lewis J Rubin
Journal:  N Engl J Med       Date:  2013-07-25       Impact factor: 91.245

5.  Bosentan added to sildenafil therapy in patients with pulmonary arterial hypertension.

Authors:  Vallerie McLaughlin; Richard N Channick; Hossein-Ardeschir Ghofrani; Jean-Christophe Lemarié; Robert Naeije; Milton Packer; Rogério Souza; Victor F Tapson; Jonathan Tolson; Hikmet Al Hiti; Gisela Meyer; Marius M Hoeper
Journal:  Eur Respir J       Date:  2015-06-25       Impact factor: 16.671

6.  Recovery from circulatory shock in severe primary pulmonary hypertension (PPH) with aerosolization of iloprost.

Authors:  H Olschewski; H A Ghofrani; D Walmrath; B Temmesfeld-Wollbrück; F Grimminger; W Seeger
Journal:  Intensive Care Med       Date:  1998-06       Impact factor: 17.440

7.  Riociguat for patients with pulmonary hypertension caused by systolic left ventricular dysfunction: a phase IIb double-blind, randomized, placebo-controlled, dose-ranging hemodynamic study.

Authors:  Diana Bonderman; Stefano Ghio; Stephan B Felix; Hossein-Ardeschir Ghofrani; Evangelos Michelakis; Veselin Mitrovic; Ronald J Oudiz; Francis Boateng; Andrea-Viviana Scalise; Lothar Roessig; Marc J Semigran
Journal:  Circulation       Date:  2013-06-17       Impact factor: 29.690

8.  Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension.

Authors:  Nazzareno Galiè; Joan A Barberà; Adaani E Frost; Hossein-Ardeschir Ghofrani; Marius M Hoeper; Vallerie V McLaughlin; Andrew J Peacock; Gérald Simonneau; Jean-Luc Vachiery; Ekkehard Grünig; Ronald J Oudiz; Anton Vonk-Noordegraaf; R James White; Christiana Blair; Hunter Gillies; Karen L Miller; Julia H N Harris; Jonathan Langley; Lewis J Rubin
Journal:  N Engl J Med       Date:  2015-08-27       Impact factor: 91.245

9.  Anticoagulation and survival in pulmonary arterial hypertension: results from the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA).

Authors:  Karen M Olsson; Marion Delcroix; H Ardeschir Ghofrani; Henning Tiede; Doerte Huscher; Rudolf Speich; Ekkehard Grünig; Gerd Staehler; Stephan Rosenkranz; Michael Halank; Matthias Held; Tobias J Lange; Juergen Behr; Hans Klose; Martin Claussen; Ralf Ewert; Christian F Opitz; C Dario Vizza; Laura Scelsi; Anton Vonk-Noordegraaf; Harald Kaemmerer; J Simon R Gibbs; Gerry Coghlan; Joanna Pepke-Zaba; Uwe Schulz; Matthias Gorenflo; David Pittrow; Marius M Hoeper
Journal:  Circulation       Date:  2013-09-30       Impact factor: 29.690

10.  Imatinib mesylate as add-on therapy for pulmonary arterial hypertension: results of the randomized IMPRES study.

Authors:  Marius M Hoeper; Robyn J Barst; Robert C Bourge; Jeremy Feldman; Adaani E Frost; Nazzareno Galié; Miguel Angel Gómez-Sánchez; Friedrich Grimminger; Ekkehard Grünig; Paul M Hassoun; Nicholas W Morrell; Andrew J Peacock; Toru Satoh; Gérald Simonneau; Victor F Tapson; Fernando Torres; David Lawrence; Deborah A Quinn; Hossein-Ardeschir Ghofrani
Journal:  Circulation       Date:  2013-02-12       Impact factor: 29.690

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  2 in total

1.  [Acute perioperative right heart insufficiency : Diagnostics and treatment].

Authors:  B Schäfer; C-A Greim
Journal:  Anaesthesist       Date:  2018-01       Impact factor: 1.041

2.  [Update pulmonary arterial hypertension : Definitions, diagnosis, therapy].

Authors:  N Sommer; M J Richter; K Tello; F Grimminger; W Seeger; H A Ghofrani; H Gall
Journal:  Internist (Berl)       Date:  2017-09       Impact factor: 0.743

  2 in total

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