Literature DB >> 27489470

Withdrawal syndrome and hypomagnesaemia and in a newborn exposed to valproic acid and carbamazepine during pregnancy.

Mehmet Satar1, Kadir Ortaköylü2, İnci Batun2, Hacer Y Yıldızdaş1, Ferda Özlü1, Hüsnü Demir3, Ali Kemal Topaloğlu4.   

Abstract

The usage of drugs during pregnancy affect the fetus and the newborn. In this report, we present findings from a newborn baby, whose mother was epileptic, and was under the treatment of valproic acid and carbamazepine during pregnancy. We have found symptoms of withdrawal syndrome, hyponatremia and feeding problem, which was most probably related to exposure to the mentioned drugs. We have also diagnosed hypomagnesaemia and atrial septal defect 4 milimeters in diameter. There are already many reports about the side effects of valproic acid and carbamazepine usage during pregnancy. To the best of our knowledge, hypomagnesaemia has not yet been reported as a side effect. We think that hypomagnesaemia is also related to the usage of antiepileptics.

Entities:  

Keywords:  Carbamazepine; hypomagnesaemia; newborn; pregnancy; valproic acid withdrawal syndrome

Year:  2016        PMID: 27489470      PMCID: PMC4959740          DOI: 10.5152/TurkPediatriArs.2016.3142

Source DB:  PubMed          Journal:  Turk Pediatri Ars


  10 in total

1.  Bicuspid aortic valve and severe aortic stenosis in a newborn exposed to carbamazapine during pregnancy.

Authors:  Zehra Karataş; Ahmet Karataş; Tülay Özlü; Sevil B Goksugur; Birgül Varan
Journal:  J Turk Ger Gynecol Assoc       Date:  2014-08-08

2.  Teratogenic effect of Carbamazepine use during pregnancy in the mice.

Authors:  Said Said Elshama; Hosam Eldin Hussein Osman; Ayman El-Meghawry El-Kenawy
Journal:  Pak J Pharm Sci       Date:  2015-01       Impact factor: 0.684

3.  Finnegan neonatal abstinence scoring system: normal values for first 3 days and weeks 5-6 in non-addicted infants.

Authors:  Urs Zimmermann-Baer; Ursula Nötzli; Katharina Rentsch; Hans Ulrich Bucher
Journal:  Addiction       Date:  2010-03       Impact factor: 6.526

4.  Newer-generation antiepileptic drugs and the risk of major birth defects.

Authors:  Ditte Mølgaard-Nielsen; Anders Hviid
Journal:  JAMA       Date:  2011-05-18       Impact factor: 56.272

Review 5.  Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024.

Authors:  António F Ambrósio; Patrício Soares-Da-Silva; Caetana M Carvalho; Arsélio P Carvalho
Journal:  Neurochem Res       Date:  2002-02       Impact factor: 3.996

Review 6.  Valproic acid monotherapy in pregnancy and major congenital malformations.

Authors:  Janneke Jentink; Maria A Loane; Helen Dolk; Ingeborg Barisic; Ester Garne; Joan K Morris; Lolkje T W de Jong-van den Berg
Journal:  N Engl J Med       Date:  2010-06-10       Impact factor: 91.245

7.  Risk of hypospadias in newborn infants exposed to valproic acid during the first trimester of pregnancy: a case-control study in Spain.

Authors:  Elvira Rodríguez-Pinilla; Consuelo Mejías; David Prieto-Merino; Paloma Fernández; María L Martínez-Frías
Journal:  Drug Saf       Date:  2008       Impact factor: 5.606

Review 8.  Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child.

Authors:  Rebecca Bromley; Jennifer Weston; Naghme Adab; Janette Greenhalgh; Anna Sanniti; Andrew J McKay; Catrin Tudur Smith; Anthony G Marson
Journal:  Cochrane Database Syst Rev       Date:  2014-10-30

9.  Neonatal episodic hypoglycemia: a finding of valproic acid withdrawal.

Authors:  Dilek Çoban; Selim Kurtoğlu; Mustafa Ali Akın; Mustafa Akçakuş; Tamer Güneş
Journal:  J Clin Res Pediatr Endocrinol       Date:  2010-05-09

10.  Fetal valproate syndrome.

Authors:  Parmarth G Chandane; Ira Shah
Journal:  Indian J Hum Genet       Date:  2014-04
  10 in total

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