Kunxue Deng1, Xun Ye2, Yaya Yang1,3, Man Liu4, Ali Ayyad5, Yuanli Zhao2, Yuyu Yuan4, Jizong Zhao2, Tao Xu1,6. 1. a Department of Mechanical Engineering , University of Texas at El Paso , El Paso , TX , USA. 2. b Beijing Translational Engineering Center for 3D printer in Clinical Neuroscience, Department of Neurosurgery, Beijing Tiantan Hospital , Capital Medical University , Beijing , China. 3. c Multidisciplinary Research Center , Shantou University , Shantou , China. 4. d School of Bioscience & Bioengineering , South China University of Technology , Guangzhou , China. 5. e Department of Neurosurgery , University Medical Centre Mainz, Johannes Gutenberg University of Mainz , Mainz , Germany. 6. f Bio-manufacturing Center, Department of Mechanical Engineering , Tsinghua University , Beijing , China.
Abstract
BACKGROUND: Numerous dura substitutes are commercially available, but no absorbable synthetic dura repair product has been used for both onlay and suture applications. OBJECTIVE: The safety and effectiveness of a new absorbable synthetic substitute composed of Poly-L-lactide microfibers as onlay dural graft were evaluated. METHODS: Physical properties and performance of the microfibrous synthetic dural substitute implanted as an onlay or suturable grafts were compared with these commercial products, including CODMAN ETHISORB™ Dura Patch and DuraGen™ Dural Graft Matrix, in a canine duraplasty model. The cerebrospinal fluid (CSF) leakage, macroscopic and microscopic observation at 30 and 90 days after implantation were investigated. RESULTS: The absorbable synthetic dural substitute exhibited good wettability and conformability. When implanted as an onlay graft, it can prevent CSF leakage and integrate with the surrounding tissue to repair dural defects, indicating its good efficacy and biocompatibility as an onlay graft. CONCLUSION: Based on the excellent physical properties and performances mentioned above, the new absorbable synthetic substitute can be applied as a dural graft for both onlay and suturable applications.
BACKGROUND: Numerous dura substitutes are commercially available, but no absorbable synthetic dura repair product has been used for both onlay and suture applications. OBJECTIVE: The safety and effectiveness of a new absorbable synthetic substitute composed of Poly-L-lactide microfibers as onlay dural graft were evaluated. METHODS: Physical properties and performance of the microfibrous synthetic dural substitute implanted as an onlay or suturable grafts were compared with these commercial products, including CODMAN ETHISORB™ Dura Patch and DuraGen™ Dural Graft Matrix, in a canine duraplasty model. The cerebrospinal fluid (CSF) leakage, macroscopic and microscopic observation at 30 and 90 days after implantation were investigated. RESULTS: The absorbable synthetic dural substitute exhibited good wettability and conformability. When implanted as an onlay graft, it can prevent CSF leakage and integrate with the surrounding tissue to repair dural defects, indicating its good efficacy and biocompatibility as an onlay graft. CONCLUSION: Based on the excellent physical properties and performances mentioned above, the new absorbable synthetic substitute can be applied as a dural graft for both onlay and suturable applications.
Authors: Ahmet Kinaci; Wilhelmina Bergmann; Ronald Law Bleys; Albert van der Zwan; Tristan Pc van Doormaal Journal: Comp Med Date: 2020-02-03 Impact factor: 0.982