| Literature DB >> 2748734 |
Y C Kong, C P Lau, K H Wat, K H Ng, P P But, K F Cheng, P G Waterman.
Abstract
Chloroform extracts of the root, stem and leaf of Ruta graveolens L. showed significant anti-fertility activity in rats when administered intragastrically on days 1-10 post-coitum. Fractionation of the extracts led to the isolation of chalepensin as the active component with some toxicity. Time-dosing experiments demonstrated that chalepensin acts at the early stages of pregnancy. It is not clear at this stage if the anti-fertility effect is a direct manifestation of chalepensin toxicity.Entities:
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Year: 1989 PMID： 2748734 DOI： 10.1055/s-2006-961917
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352