| Literature DB >> 27487320 |
Joseph W Meisel1, Mohit B Patel1, Evan Garrad1, Ryan A Stanton1, George W Gokel1.
Abstract
Nine bis(tryptophan) derivatives (BTs) and two control compounds were synthesized and tested for antimicrobial activity against two Escherichia coli strains and a Staphylococcus aureus strain. The effects of linker type, shape, and conformational rigidity were manifested in dramatic differences in altering tetracycline potency when coadministered with that antibiotic. A reversal of resistance was observed for an E. coli strain having a TetA efflux pump. Survival of mammalian cells was assayed with good result.Entities:
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Year: 2016 PMID： 27487320 DOI： 10.1021/jacs.6b05578
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419