| Literature DB >> 2748728 |
A Panthong, W Tassaneeyakul, D Kanjanapothi, P Tantiwachwuttikul, V Reutrakul.
Abstract
The anti-inflammatory activity of 5,7-dimethoxyflavone (5,7-DMF) has been assessed. It was found to possess a comparable effect to aspirin on the rat paw edema model, and it showed no inhibition on cotton pellet-induced granuloma formation. On the rat pleurisy model, 5,7-DMF exhibited an antiexudative effect, interfered with leukocyte migration, and markedly inhibited prostaglandin biosynthesis. In addition, 5,7-DMF caused marked lowering of the rectal temperature of rats. The results obtained from Hippocratic screening revealed that 5,7-DMF possessed a weak CNS depressant activity.Entities:
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Year: 1989 PMID： 2748728 DOI： 10.1055/s-2006-961905
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352