Photios Vassilyadi1, Scott V Harding1,2, Tom J Hazell1,3, Hope A Weiler1, Linda J Wykes1. 1. School of Dietetics and Human Nutrition, McGill University, Montreal, Quebec, Canada. 2. Diabetes and Nutritional Sciences Division, Faculty of Life Sciences and Medicine, King's College, London, UK. 3. Department of Kinesiology and Physical Education, Wilfrid Laurier University, Waterloo, Ontario, Canada.
Abstract
BACKGROUND: Deterioration in bone health is a concern in managing pediatric inflammatory bowel diseases, but clear understanding of the independent contributions of disease and nutrition is lacking. This study aimed to ascertain whether bone health could be conserved during colitis by maintaining adequate nutritional intake in growing piglets. METHODS: The effect of colitis on bone structure and strength was determined in piglets with dextran sulphate sodium-induced colitis. Piglets received either 100% macro/micronutrient requirements or 50% macro/100% micronutrient requirements. Femurs were analyzed for dual-energy x-ray absorptiometry, peripheral quantitative computed tomography, microcomputed tomography, and 3-point bending tests. RESULTS: Colitis, regardless of a well-nourished or malnourished diet, compromised areal bone mineral density (-17%) and volumetric bone mineral density (-20%) in cortical and trabecular bone. Structural integrity at mid-diaphysis was maintained during colitis; however, lower cortical area, trabecular area, and bone mineral content resulted in lower energy to break. CONCLUSION: Colitis compromises both bone structure and strength of long bones in piglets, independent of macronutrient intakes. Although confirmation of these findings in pediatric cohorts is needed, these data identify aspects of bone health that may be affected by inflammatory bowel disease.
BACKGROUND: Deterioration in bone health is a concern in managing pediatric inflammatory bowel diseases, but clear understanding of the independent contributions of disease and nutrition is lacking. This study aimed to ascertain whether bone health could be conserved during colitis by maintaining adequate nutritional intake in growing piglets. METHODS: The effect of colitis on bone structure and strength was determined in piglets with dextran sulphate sodium-induced colitis. Piglets received either 100% macro/micronutrient requirements or 50% macro/100% micronutrient requirements. Femurs were analyzed for dual-energy x-ray absorptiometry, peripheral quantitative computed tomography, microcomputed tomography, and 3-point bending tests. RESULTS:Colitis, regardless of a well-nourished or malnourished diet, compromised areal bone mineral density (-17%) and volumetric bone mineral density (-20%) in cortical and trabecular bone. Structural integrity at mid-diaphysis was maintained during colitis; however, lower cortical area, trabecular area, and bone mineral content resulted in lower energy to break. CONCLUSION:Colitis compromises both bone structure and strength of long bones in piglets, independent of macronutrient intakes. Although confirmation of these findings in pediatric cohorts is needed, these data identify aspects of bone health that may be affected by inflammatory bowel disease.
Authors: Andrew S Day; Kylie E Whitten; Daniel A Lemberg; Cathy Clarkson; Maribel Vitug-Sales; Reuben Jackson; Tim D Bohane Journal: J Gastroenterol Hepatol Date: 2006-10 Impact factor: 4.029
Authors: Kylie E Whitten; Steven T Leach; Timothy D Bohane; Helen J Woodhead; Andrew S Day Journal: J Gastroenterol Date: 2009-12-03 Impact factor: 7.527
Authors: Mostafa Abdel-Aziz El-Hodhod; Ahmad Mohamed Hamdy; Amal Ahmed Abbas; Sherine George Moftah; Alhag Ahmed Mohamed Ramadan Journal: BMC Gastroenterol Date: 2012-05-02 Impact factor: 3.067