Literature DB >> 27486493

Exercise Intolerance In Heart Failure With Preserved Ejection Fraction.

Anisha A Gupte1, Dale J Hamilton2.   

Abstract

More than 50% of Americans with heart failure have preserved ejection fraction (HFpEF). Exercise intolerance is a hallmark of HFpEF, but the pathophysiology is not well understood. Diverse etiologies and incomplete mechanistic understanding have resulted in ineffective management strategies to improve the outcomes of HFpEF. Traditional therapies that have been beneficial in the treatment of heart failure with reduced ejection fraction (HFrEF), neurohormonal blockade in particular, have not been effective in treating HFpEF. In this review, we address underlying mechanisms of HFpEF and present the rationale supporting exercise as a component of comprehensive management.

Entities:  

Keywords:  diastolic dysfunction; exercise intolerance; exercise therapy; heart failure with preserved ejection fraction; impaired diastolic function; metabolic and bioenergetic factors

Mesh：

Year:  2016        PMID： 27486493      PMCID： PMC4969017          DOI： 10.14797/mdcj-12-2-105

Source DB:  PubMed          Journal:  Methodist Debakey Cardiovasc J        ISSN： 1947-6108


  30 in total

1.  Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.

Authors:  Timothy R Koves; John R Ussher; Robert C Noland; Dorothy Slentz; Merrie Mosedale; Olga Ilkayeva; James Bain; Robert Stevens; Jason R B Dyck; Christopher B Newgard; Gary D Lopaschuk; Deborah M Muoio
Journal:  Cell Metab       Date:  2008-01       Impact factor: 27.287

Review 2.  Heart failure with preserved ejection fraction: mechanisms, clinical features, and therapies.

Authors:  Kavita Sharma; David A Kass
Journal:  Circ Res       Date:  2014-06-20       Impact factor: 17.367

3.  Determinants of exercise intolerance in elderly heart failure patients with preserved ejection fraction.

Authors:  Mark J Haykowsky; Peter H Brubaker; Jerry M John; Kathryn P Stewart; Timothy M Morgan; Dalane W Kitzman
Journal:  J Am Coll Cardiol       Date:  2011-07-12       Impact factor: 24.094

Review 4.  Heart failure with preserved ejection fraction: molecular pathways of the aging myocardium.

Authors:  Francesco S Loffredo; Andriana P Nikolova; James R Pancoast; Richard T Lee
Journal:  Circ Res       Date:  2014-06-20       Impact factor: 17.367

Review 5.  Heart failure with preserved ejection fraction in the elderly: scope of the problem.

Authors:  Bharathi Upadhya; George E Taffet; Che Ping Cheng; Dalane W Kitzman
Journal:  J Mol Cell Cardiol       Date:  2015-03-06       Impact factor: 5.000

6.  Mechanisms of exercise intolerance in heart failure with preserved ejection fraction: the role of abnormal peripheral oxygen extraction.

Authors:  Bishnu P Dhakal; Rajeev Malhotra; Ryan M Murphy; Paul P Pappagianopoulos; Aaron L Baggish; Rory B Weiner; Nicholas E Houstis; Aaron S Eisman; Stacyann S Hough; Gregory D Lewis
Journal:  Circ Heart Fail       Date:  2014-10-24       Impact factor: 8.790

7.  Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study.

Authors:  Frank Edelmann; Götz Gelbrich; Hans-Dirk Düngen; Stefan Fröhling; Rolf Wachter; Raoul Stahrenberg; Lutz Binder; Agnieszka Töpper; Diana Jahandar Lashki; Silja Schwarz; Christoph Herrmann-Lingen; Markus Löffler; Gerd Hasenfuss; Martin Halle; Burkert Pieske
Journal:  J Am Coll Cardiol       Date:  2011-10-18       Impact factor: 24.094

8.  Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness.

Authors:  Kim M Huffman; Timothy R Koves; Monica J Hubal; Hiba Abouassi; Nina Beri; Lori A Bateman; Robert D Stevens; Olga R Ilkayeva; Eric P Hoffman; Deborah M Muoio; William E Kraus
Journal:  Diabetologia       Date:  2014-08-05       Impact factor: 10.122

9.  Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency.

Authors:  Thanh T Phan; Khalid Abozguia; Ganesh Nallur Shivu; Gnanadevan Mahadevan; Ibrar Ahmed; Lynne Williams; Girish Dwivedi; Kiran Patel; Paul Steendijk; Houman Ashrafian; Anke Henning; Michael Frenneaux
Journal:  J Am Coll Cardiol       Date:  2009-07-28       Impact factor: 24.094

10.  Noninvasive Detection of Early Metabolic Left Ventricular Remodeling in Systemic Hypertension.

Authors:  Yasmin S Hamirani; Bijoy K Kundu; Min Zhong; Andrew McBride; Yinlin Li; Giovanni E Davogustto; Heinrich Taegtmeyer; Jamieson M Bourque
Journal:  Cardiology       Date:  2015-11-24       Impact factor: 1.869
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  9 in total

Review 1.  Revisiting the physiological effects of exercise training on autonomic regulation and chemoreflex control in heart failure: does ejection fraction matter?

Authors:  David C Andrade; Alexis Arce-Alvarez; Camilo Toledo; Hugo S Díaz; Claudia Lucero; Rodrigo A Quintanilla; Harold D Schultz; Noah J Marcus; Markus Amann; Rodrigo Del Rio
Journal:  Am J Physiol Heart Circ Physiol       Date:  2017-11-22       Impact factor: 4.733

2.  Carvedilol and exercise combination therapy improves systolic but not diastolic function and reduces plasma osteopontin in Col4a3-/- Alport mice.

Authors:  Julian C Dunkley; Camila I Irion; Keyvan Yousefi; Serene A Shehadeh; Guerline Lambert; Krista John-Williams; Keith A Webster; Jeffrey J Goldberger; Lina A Shehadeh
Journal:  Am J Physiol Heart Circ Physiol       Date:  2021-03-26       Impact factor: 4.733

Review 3.  Relationships among norepinephrine levels, exercise capacity, and chronotropic responses in heart failure patients.

Authors:  Liza Grosman-Rimon; Evan Wright; Solomon Sabovich; Jordan Rimon; Sagi Gleitman; Doron Sudarsky; Alla Lubovich; Itzhak Gabizon; Spencer D Lalonde; Sharon Tsuk; Michael A McDonald; Vivek Rao; David Gutterman; Ulrich P Jorde; Shemy Carasso; Erez Kachel
Journal:  Heart Fail Rev       Date:  2022-03-24       Impact factor: 4.214

4.  Voluntary Exercise Improves Cardiac Function and Prevents Cardiac Remodeling in a Mouse Model of Dilated Cardiomyopathy.

Authors:  Robin Deloux; Damien Vitiello; Nathalie Mougenot; Philippe Noirez; Zhenlin Li; Mathias Mericskay; Arnaud Ferry; Onnik Agbulut
Journal:  Front Physiol       Date:  2017-11-15       Impact factor: 4.566

5.  Characterization of Cardiopulmonary Exercise Testing Variables in Patients with Endomyocardial Fibrosis after Endocardial Resection.

Authors:  Ana Luiza C Sayegh; Marcelo R Dos Santos; Patricia de Oliveira; Fábio Fernandes; Eduardo Rondon; Francis R de Souza; Vera M C Salemi; Maria Janieire de N N Alves; Charles Mady
Journal:  Arq Bras Cardiol       Date:  2017-12       Impact factor: 2.000

6.  Type-2 diabetic aldehyde dehydrogenase 2 mutant mice (ALDH 2*2) exhibiting heart failure with preserved ejection fraction phenotype can be determined by exercise stress echocardiography.

Authors:  Guodong Pan; Srikar Munukutla; Ananya Kar; Joseph Gardinier; Rajarajan A Thandavarayan; Suresh Selvaraj Palaniyandi
Journal:  PLoS One       Date:  2018-04-20       Impact factor: 3.752

Review 7.  Effects of spironolactone in heart failure with preserved ejection fraction: A meta-analysis of randomized controlled trials.

Authors:  Shuai Li; Xinling Zhang; Mei Dong; Shu Gong; Zhi Shang; Xu Jia; Wenqiang Chen; Jianmin Yang; Jifu Li
Journal:  Medicine (Baltimore)       Date:  2018-08       Impact factor: 1.817

8.  Motivational interviewing can support physical activity in elderly patients with diastolic heart failure: results from a pilot study.

Authors:  Anna Schertz; Birgit Herbeck Belnap; Mira-Lynn Chavanon; Frank Edelmann; Rolf Wachter; Christoph Herrmann-Lingen
Journal:  ESC Heart Fail       Date:  2019-04-08

9.  Exercise intolerance in volume overload heart failure is associated with low carotid body mediated chemoreflex drive.

Authors:  David C Andrade; Esteban Díaz-Jara; Camilo Toledo; Karla G Schwarz; Katherin V Pereyra; Hugo S Díaz; Noah J Marcus; Fernando C Ortiz; Angélica P Ríos-Gallardo; Domiziana Ortolani; Rodrigo Del Rio
Journal:  Sci Rep       Date:  2021-07-14       Impact factor: 4.379
  9 in total

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