Ameet Patki1, Naveen Chauhan2. 1. K. J. Somaiya Medical College, Hospital & Research Centre, Mumbai, 400022 India. 2. Medical Sciences Division, Abbott India Limited, 3-4 Corporate Park, Sion-Trombay Road, Mumbai, 400071 India.
Abstract
BACKGROUND: The data on the prevalence of recurrent spontaneous miscarriage (RSM) in India are scarce. This study aimed to determine the prevalence of RSM in Indian females. METHODS: Female patients aged between 18 and 45 years with history of at least one spontaneous miscarriage were enrolled in the study. The probability of a subsequent miscarriage after the first, second, and third miscarriage was determined. The prevalence of RSM (defined as loss of ≥3 pregnancies of ≤20 weeks gestation each) between different age groups was compared using χ (2) test. Binary logistic regression analysis was applied to determine any association between RSM and the presence of risk factors. RESULTS: Of the 2398 patients screened for eligibility, 767 (32 %) had a history of at least one spontaneous miscarriage. The prevalence of RSM among the 753 enrolled patients who satisfied the eligibility criteria in the study was 7.46 %. RSM was mostly recorded in the age group of ≥33 years (14.68 %, n = 32). In patients with RSM, the second and third miscarriages were more prevalent during 7th week to end of 11th week of gestation. The probability of having a subsequent miscarriage after the first, second, and third miscarriage was 0.25, 0.34, and 0.22, respectively. There was a significant association (p < 0.05) between RSM and clotting disorders, immunological factors, infections, and genetic disorders. CONCLUSION: The study revealed a higher prevalence of RSM among the Indian women as compared to western data. Age, clotting disorders, immunological factors, infections, and genetic disorders were the significant risk factors associated with RSM.
BACKGROUND: The data on the prevalence of recurrent spontaneous miscarriage (RSM) in India are scarce. This study aimed to determine the prevalence of RSM in Indian females. METHODS: Female patients aged between 18 and 45 years with history of at least one spontaneous miscarriage were enrolled in the study. The probability of a subsequent miscarriage after the first, second, and third miscarriage was determined. The prevalence of RSM (defined as loss of ≥3 pregnancies of ≤20 weeks gestation each) between different age groups was compared using χ (2) test. Binary logistic regression analysis was applied to determine any association between RSM and the presence of risk factors. RESULTS: Of the 2398 patients screened for eligibility, 767 (32 %) had a history of at least one spontaneous miscarriage. The prevalence of RSM among the 753 enrolled patients who satisfied the eligibility criteria in the study was 7.46 %. RSM was mostly recorded in the age group of ≥33 years (14.68 %, n = 32). In patients with RSM, the second and third miscarriages were more prevalent during 7th week to end of 11th week of gestation. The probability of having a subsequent miscarriage after the first, second, and third miscarriage was 0.25, 0.34, and 0.22, respectively. There was a significant association (p < 0.05) between RSM and clotting disorders, immunological factors, infections, and genetic disorders. CONCLUSION: The study revealed a higher prevalence of RSM among the Indian women as compared to western data. Age, clotting disorders, immunological factors, infections, and genetic disorders were the significant risk factors associated with RSM.
Authors: Giovanni Nigro; Manuela Mazzocco; Elisabetta Mattia; Gian Carlo Di Renzo; Gaspare Carta; Maurizio M Anceschi Journal: J Matern Fetal Neonatal Med Date: 2011-01-24
Authors: Lu Li; Ping Chung Leung; Tony Kwok Hung Chung; Chi Chiu Wang Journal: Evid Based Complement Alternat Med Date: 2014-02-05 Impact factor: 2.629
Authors: Sangappa M Dhaded; Manjunath S Somannavar; Jane P Jacob; Elizabeth M McClure; Sunil S Vernekar; S Yogesh Kumar; Avinash Kavi; Umesh Y Ramadurg; Janet L Moore; Dennis P Wallace; Richard J Derman; Robert L Goldenberg; Shivaprasad S Goudar Journal: Reprod Health Date: 2018-06-22 Impact factor: 3.223