Arkan Abadi1, Jesus Peralta-Romero2, Fernando Suarez2, Jaime Gomez-Zamudio2, Ana I Burguete-Garcia3, Miguel Cruz2, David Meyre1,4. 1. Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada. 2. Medical Research Unit in Biochemistry, Hospital de Especialidades, Centro Médico Nacional Siglo XXI del Instituto Mexicano del Seguro Social, Mexico City, Mexico. 3. Centro de investigación sobre enfermedades infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico. 4. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Abstract
OBJECTIVE: The prevalence of obesity in Mexico has increased at an alarming rate in both adults and children. This study was undertaken to test in Mexican children the effects of single nucleotide polymorphisms (SNP) that have been associated with body mass index (BMI) and obesity in Europeans. METHODS: School-age children (N = 1,559, 5-17 years) were recruited in Mexico City. Thirty-five SNPs with established effects on BMI and obesity were genotyped and analyzed individually and as a combined gene score (GS). RESULTS: SNPs in FAIM2 (rs7138803), GPRC5BB (rs12444979), MTIF3 (rs4771122), TFAP2B (rs987237), TMEM18 (rs7561317), and the GS were significantly associated with BMI. The GS explained 0.9% of the variance of BMI. Also, SNPs in LRRN6C (rs10968576) and MC4R (rs17782313) were significantly associated with overweight and obesity categories, respectively. Importantly, the effect allele frequency of 26/35 SNPs (74.3%) differed significantly between Mexican children and European adults. No significant gene × environment or gene × gene interactions were detected after Bonferroni adjustment. CONCLUSIONS: Several SNPs first associated with BMI/obesity in European adults replicated well in Mexican children, and investigating differences in the distribution of effect alleles across ethnic populations may shed light on genetic susceptibilities of different populations to obesity.
OBJECTIVE: The prevalence of obesity in Mexico has increased at an alarming rate in both adults and children. This study was undertaken to test in Mexican children the effects of single nucleotide polymorphisms (SNP) that have been associated with body mass index (BMI) and obesity in Europeans. METHODS: School-age children (N = 1,559, 5-17 years) were recruited in Mexico City. Thirty-five SNPs with established effects on BMI and obesity were genotyped and analyzed individually and as a combined gene score (GS). RESULTS: SNPs in FAIM2 (rs7138803), GPRC5BB (rs12444979), MTIF3 (rs4771122), TFAP2B (rs987237), TMEM18 (rs7561317), and the GS were significantly associated with BMI. The GS explained 0.9% of the variance of BMI. Also, SNPs in LRRN6C (rs10968576) and MC4R (rs17782313) were significantly associated with overweight and obesity categories, respectively. Importantly, the effect allele frequency of 26/35 SNPs (74.3%) differed significantly between Mexican children and European adults. No significant gene × environment or gene × gene interactions were detected after Bonferroni adjustment. CONCLUSIONS: Several SNPs first associated with BMI/obesity in European adults replicated well in Mexican children, and investigating differences in the distribution of effect alleles across ethnic populations may shed light on genetic susceptibilities of different populations to obesity.
Authors: Christine Langlois; Arkan Abadi; Jesus Peralta-Romero; Akram Alyass; Fernando Suarez; Jaime Gomez-Zamudio; Ana I Burguete-Garcia; Fereshteh T Yazdi; Miguel Cruz; David Meyre Journal: Sci Rep Date: 2016-10-26 Impact factor: 4.379
Authors: Junling Fu; Ge Li; Lujiao Li; Jinhua Yin; Hong Cheng; Lanwen Han; Qian Zhang; Naishi Li; Xinhua Xiao; Struan F A Grant; Mingyao Li; Shan Gao; Jie Mi; Ming Li Journal: Oncotarget Date: 2017-08-24
Authors: Paola León-Mimila; Hugo Villamil-Ramírez; Blanca E López-Contreras; Sofía Morán-Ramos; Luis R Macias-Kauffer; Víctor Acuña-Alonzo; Blanca E Del Río-Navarro; Jorge Salmerón; Rafael Velazquez-Cruz; Teresa Villarreal-Molina; Carlos A Aguilar-Salinas; Samuel Canizales-Quinteros Journal: Nutrients Date: 2018-11-01 Impact factor: 5.717