Heng Zhou1,2, Qixin Zhou3, Lin Xu4,5. 1. School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, People's Republic of China. 2. Laboratory of Learning and Memory, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, CAS, Kunming, 650223, People's Republic of China. 3. Laboratory of Learning and Memory, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, CAS, Kunming, 650223, People's Republic of China. qixin_zhou@126.com. 4. Laboratory of Learning and Memory, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, CAS, Kunming, 650223, People's Republic of China. lxu@vip.163.com. 5. Kunming College of Life Sciences, University of Chinese Academy of Sciences, Kunming, People's Republic of China. lxu@vip.163.com.
Abstract
RATIONALE: Contextual fear memory depends on the hippocampus, but the role of unilateral hippocampus in this type of memory remains unclear. OBJECTIVES: Herein, pharmacological inactivation or excitotoxic lesions were used to study the role of unilateral hippocampus in the stages of contextual fear memory. RESULTS: The pharmacological experiments revealed that compared with the control groups, unilateral hippocampal blockade did not impair 1-day recent memory following learning, whereas bilateral hippocampal blockade significantly impaired this memory. The lesion experiments showed that compared with the control groups, the formed contextual fear memory was retained for 7 days and that 30-day remote memory was markedly reduced in unilateral hippocampal lesion groups. CONCLUSIONS: These results indicate that an intact bilateral hippocampus is required for the formation of remote memory and that unilateral hippocampus is sufficient for recent contextual fear memory.
RATIONALE: Contextual fear memory depends on the hippocampus, but the role of unilateral hippocampus in this type of memory remains unclear. OBJECTIVES: Herein, pharmacological inactivation or excitotoxic lesions were used to study the role of unilateral hippocampus in the stages of contextual fear memory. RESULTS: The pharmacological experiments revealed that compared with the control groups, unilateral hippocampal blockade did not impair 1-day recent memory following learning, whereas bilateral hippocampal blockade significantly impaired this memory. The lesion experiments showed that compared with the control groups, the formed contextual fear memory was retained for 7 days and that 30-day remote memory was markedly reduced in unilateral hippocampal lesion groups. CONCLUSIONS: These results indicate that an intact bilateral hippocampus is required for the formation of remote memory and that unilateral hippocampus is sufficient for recent contextual fear memory.
Authors: Charlotte S M Schmidt; Maryse Lassonde; Louise Gagnon; Catherine H Sauerwein; Lionel Carmant; Philippe Major; Natacha Paquette; Franco Lepore; Anne Gallagher Journal: Epilepsy Behav Date: 2015-01-16 Impact factor: 2.937
Authors: Emma L Wignall; Jon M Dickson; Paul Vaughan; Tom F D Farrow; Iain D Wilkinson; Michael D Hunter; Peter W R Woodruff Journal: Biol Psychiatry Date: 2004-12-01 Impact factor: 13.382
Authors: Irena Štěpán-Buksakowska; Nikoletta Szabó; Daniel Hořínek; Eszter Tóth; Jakub Hort; Joshua Warner; František Charvát; László Vécsei; Miloslav Roček; Zsigmond T Kincses Journal: Alzheimer Dis Assoc Disord Date: 2014 Jan-Mar Impact factor: 2.703
Authors: Jessica C Jimenez; Jack E Berry; Sean C Lim; Samantha K Ong; Mazen A Kheirbek; Rene Hen Journal: Nat Commun Date: 2020-07-13 Impact factor: 14.919
Authors: Remko Kockelkoren; Jill B De Vis; M Stavenga; Willem P Th M Mali; Jeroen Hendrikse; Annemieke M Rozemuller; Huiberdina L Koek; Irene C van der Schaaf; Birgitta K Velthuis; Pim A de Jong Journal: Eur Radiol Date: 2018-04-04 Impact factor: 5.315