Zhibo Chen1, Zhongqian Su1, Wanhui Pang1, Yuanyuan Huang1, Jie Lin1, Zhangna Ding2, Senmin Wu3, Shunyao Xu4, Weiwei Quan1, Juzeng Zheng5, Huale Chen6, Zhengzheng Li1, Xiang Li1, Jia Li1, Yiyun Weng1, Xu Zhang1. 1. a Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China. 2. b Department of Intensive Care Unit, Ruian People's Hospital, The Third Affiliated Hospital of Wenzhou Medical University , Wenzhou , China. 3. c Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China. 4. d Department of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China. 5. e Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China. 6. f Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
Abstract
OBJECTIVE: Oxidative stress and variations in antioxidant status are implicated in the pathogenesis of inflammatory and autoimmune diseases. Polymyositis and dermatomyositis (PM/DM) are autoimmune diseases with inflammatory cells infiltrating into skeletal muscles, and the antioxidant status is still controversial. The aim of our study was to investigate the correlation between PM/DM and the antioxidant status of serum bilirubin (Tbil, Dbil and Ibil) and uric acid (UA). MATERIALS AND METHODS: We measured serum concentrations of bilirubin (Tbil, Dbil and Ibil) and uric acid in 384 individuals, including 110 PM/DM patients and 274 healthy controls. RESULTS: We found that PM/DM patients had significantly lower serum concentrations of bilirubin (Tbil and Ibil) and uric acid than healthy controls, whether male or female. Also, after separately adjusting the covariances of age and gender, Tbil, Dbil, Ibil and UA were all relevant factors for PM/DM. Moreover, there were no significant differences in serum antioxidant molecule levels between PM and DM subgroups. CONCLUSION: Our study demonstrated the low serum levels of bilirubin and uric acid in patients with PM/DM. This suggested low antioxidant status in PM/DM patients with excessive oxidative stress.
OBJECTIVE: Oxidative stress and variations in antioxidant status are implicated in the pathogenesis of inflammatory and autoimmune diseases. Polymyositis and dermatomyositis (PM/DM) are autoimmune diseases with inflammatory cells infiltrating into skeletal muscles, and the antioxidant status is still controversial. The aim of our study was to investigate the correlation between PM/DM and the antioxidant status of serum bilirubin (Tbil, Dbil and Ibil) and uric acid (UA). MATERIALS AND METHODS: We measured serum concentrations of bilirubin (Tbil, Dbil and Ibil) and uric acid in 384 individuals, including 110 PM/DMpatients and 274 healthy controls. RESULTS: We found that PM/DMpatients had significantly lower serum concentrations of bilirubin (Tbil and Ibil) and uric acid than healthy controls, whether male or female. Also, after separately adjusting the covariances of age and gender, Tbil, Dbil, Ibil and UA were all relevant factors for PM/DM. Moreover, there were no significant differences in serum antioxidant molecule levels between PM and DM subgroups. CONCLUSION: Our study demonstrated the low serum levels of bilirubin and uric acid in patients with PM/DM. This suggested low antioxidant status in PM/DMpatients with excessive oxidative stress.