Literature DB >> 27484603

Nonsurgical Periodontal Therapy decreases the Severity of Rheumatoid Arthritis: A Case-control Study.

Neha Khare1, Bhavuk Vanza2, Deepak Sagar3, Kumar Saurav4, Rohit Chauhan4, Supriya Mishra5.   

Abstract

INTRODUCTION: Rheumatoid arthritis (RA) and periodontitis are common chronic inflammatory conditions. Several studies suggested a relationship between RA and periodontitis. Recent studies have shown a beneficial effect of periodontal treatment on the severity of active RA. So the aim of this study was to examine the effect of nonsurgical periodontal therapy on the clinical parameters of RA.
MATERIALS AND METHODS: A total of 60 subjects with moderate-to-severe chronic generalized periodontitis and active RA in the age range 18 to 65 were selected for the study. They were divided into two groups. Group A (control group) consisted of 30 subjects with chronic generalized periodontitis and RA, and group B of 30 subjects with chronic generalized peri-odontitis and RA and they received nonsurgical periodontal therapy (scaling, root planning, and oral hygiene instructions). Evaluation of clinical observations of Simplified Oral Hygiene Index (OHI-S), gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment level (CAL), number of swollen joints (SJ), number of tender joints (TJ), values of erythrocyte sedimentation rate (ESR), visual analogue scale (VAS) for patient's global assessment, 3 months disease activity score (DAS) index, and C-reactive protein (CRP) was done at baseline and 3 months. Statistical evaluation of clinical observations was carried out.
RESULTS: Group B subjects who received nonsurgical periodon-tal therapy showed statistically significant improvement in all periodontal and RA parameters at 3 months, compared with group A who did not receive periodontal therapy.
CONCLUSION: It can be concluded from the result that nonsurgical periodontal therapy may contribute to reduction in severity and symptoms of RA. CLINICAL SIGNIFICANCE: Rheumatoid arthritis patients should be evaluated for periodontitis and treated for the same in order to reduce its severity level.

Entities:  

Keywords:  Inflammation; Periodontitis; Rheumatoid arthritis.

Mesh:

Year:  2016        PMID: 27484603     DOI: 10.5005/jp-journals-10024-1877

Source DB:  PubMed          Journal:  J Contemp Dent Pract        ISSN: 1526-3711


  10 in total

Review 1.  The case for periodontitis in the pathogenesis of rheumatoid arthritis.

Authors:  Jan Potempa; Piotr Mydel; Joanna Koziel
Journal:  Nat Rev Rheumatol       Date:  2017-08-24       Impact factor: 20.543

Review 2.  Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications.

Authors:  George Hajishengallis
Journal:  Periodontol 2000       Date:  2022-03-04       Impact factor: 12.239

Review 3.  Maladaptive trained immunity and clonal hematopoiesis as potential mechanistic links between periodontitis and inflammatory comorbidities.

Authors:  George Hajishengallis; Xiaofei Li; Kimon Divaris; Triantafyllos Chavakis
Journal:  Periodontol 2000       Date:  2022-03-04       Impact factor: 12.239

4.  Non-surgical periodontal treatment improves rheumatoid arthritis disease activity: a meta-analysis.

Authors:  Jia Sun; Youli Zheng; Xiaowei Bian; Huijian Ge; Jun Wang; Zheng Zhang
Journal:  Clin Oral Investig       Date:  2021-01-29       Impact factor: 3.573

5.  Association of Periodontitis with Rheumatoid Arthritis and the Effect of Non-Surgical Periodontal Treatment on Disease Activity in Patients with Rheumatoid Arthritis.

Authors:  Xinyuan Zhao; Zhongjun Liu; Dalong Shu; Yanlin Xiong; Minzhao He; Shuaimei Xu; Shanhan Si; Bing Guo
Journal:  Med Sci Monit       Date:  2018-08-20

6.  Non-surgical oral hygiene interventions on disease activity of Rheumatoid arthritis patients with periodontitis: A randomized controlled trial.

Authors:  William Buwembo; Ian Guyton Munabi; Mark Kaddumukasa; Haruna Kiryowa; Muhammad Mbabali; Ethel Nankya; William Evan Johnson; Emmy Okello; Nelson K Sewankambo
Journal:  J Dent Res Dent Clin Dent Prospects       Date:  2020

7.  Salivary interleukin 6, interleukin 8, interleukin 17A, and tumour necrosis factor α levels in patients with periodontitis and rheumatoid arthritis.

Authors:  Tomasz Kaczyński; Jakub Wroński; Piotr Głuszko; Tomasz Kryczka; Andrzej Miskiewicz; Bartłomiej Górski; Marek Radkowski; Damian Strzemecki; Paweł Grieb; Renata Górska
Journal:  Cent Eur J Immunol       Date:  2019-09-30       Impact factor: 2.085

Review 8.  Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities.

Authors:  George Hajishengallis; Triantafyllos Chavakis
Journal:  Nat Rev Immunol       Date:  2021-01-28       Impact factor: 108.555

Review 9.  Does non-surgical periodontal treatment influence on rheumatoid arthritis? A systematic review and meta-analysis.

Authors:  Cleber Davi Del Rei Daltro Rosa; Jéssica Marcela de Luna Gomes; Sandra Lúcia Dantas de Moraes; Cleidiel Aparecido Araujo Lemos; Lurian Minatel; João Pedro Justino de Oliveira Limirio; Eduardo Piza Pellizzer
Journal:  Saudi Dent J       Date:  2021-09-14

Review 10.  Does periodontal treatment improve rheumatoid arthritis disease activity? A systematic review.

Authors:  Zhain Mustufvi; Joshua Twigg; Joel Kerry; James Chesterman; Sue Pavitt; Aradhna Tugnait; Kulveer Mankia
Journal:  Rheumatol Adv Pract       Date:  2022-08-17
  10 in total

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