Literature DB >> 27483434

Luminescent platforms for monitoring changes in the solubility of amylin and huntingtin in living cells.

Jia Zhao1, Quyen Vu, Cliff I Stains.   

Abstract

Luminescent, cell-based assays capable of monitoring the aggregation potential of the disease-relevant proteins known as amylin (type 2 diabetes) and huntingtin (Huntington's disease) are presented. These sensitive platforms report on the influence of mutations as well as small molecules on protein solubility.

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Year:  2016        PMID： 27483434     DOI： 10.1039/c6mb00454g

Source DB:  PubMed          Journal:  Mol Biosyst        ISSN： 1742-2051


  3 in total

Review 1.  Direct visualization and profiling of protein misfolding and aggregation in live cells.

Authors:  Sicheng Tang; Wenting Wang; Xin Zhang
Journal:  Curr Opin Chem Biol       Date:  2021-07-08       Impact factor: 8.972

2.  A Luminescence-Based System for Identification of Genetically Encodable Inhibitors of Protein Aggregation.

Authors:  Travis J Nelson; Shuo Liang; Cliff I Stains
Journal:  ACS Omega       Date:  2020-05-29

3.  A luminescence-based assay for monitoring changes in alpha-synuclein aggregation in living cells.

Authors:  Travis J Nelson; Tiffany Truong; BaoLong Truong; Camden V Bilyeu; Jia Zhao; Cliff I Stains
Journal:  RSC Adv       Date:  2020-04-28       Impact factor: 3.361
  3 in total

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