| Literature DB >> 27481530 |
Sikhulile Moyo1,2, Kenanao P Kotokwe2, Terence Mohammed2, Corretah Boleo2, Lucy Mupfumi2, Samuel Chishala1,3, Lesedi Tsalaile1, Hermann Bussmann2,4, Simani Gaseitsiwe2,4, Rosemary Musonda2,4, Joseph Makhema2,4, Marianna Baum5, Richard Marlink2,4, Susan Engelbrecht1,6, Max Essex2,4, Vladimir Novitsky2,4.
Abstract
Cross-sectional estimation of HIV incidence could misclassify some established or chronic HIV infections as recent. Usually long-term nonprogressors, elite and viremic controllers, and individuals on ART contribute to misclassification. Local data on the false recent rate (FRR) could minimize misclassification during estimation of HIV incidence. To improve monitoring of HIV incidence, we estimated local FRR in Botswana. A total of 1,036 specimens from individuals infected for at least 1.5-2 years were sampled between 2004 and 2009 and tested using the limiting antigen (LAg)-avidity assay using a cutoff of 1.5 normalized optical density units. The FRR was 0.97% (10/1,036; 95% confidence interval [CI] 0.46-1.77). Four samples had HIV-1 RNA >1,000 cps/ml, giving an adjusted FRR of 0.39% (4/1,036; 95% CI 0.11-0.99). A combination of LAg and HIV-1 RNA load data resulted in FRR below 1% in the Botswana population.Entities:
Keywords: HIV incidence; HIV recency; cross-sectional incidence; false recency rate; limiting antigen assay
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Year: 2016 PMID： 27481530 PMCID： PMC5239999 DOI： 10.1089/AID.2016.0127
Source DB: PubMed Journal: AIDS Res Hum Retroviruses ISSN： 0889-2229 Impact factor: 2.205