Literature DB >> 27481327

Mechanochemical Strecker Reaction: Access to α-Aminonitriles and Tetrahydroisoquinolines under Ball-Milling Conditions.

José G Hernández1, Mathias Turberg1, Ingo Schiffers1, Carsten Bolm2.   

Abstract

A mechanochemical version of the Strecker reaction for the synthesis of α-aminonitriles was developed. The milling of aldehydes, amines, and potassium cyanide in the presence of SiO2 gave the corresponding α-aminonitriles in good to high yields. The high efficiency of the mechanochemical Strecker-type multicomponent reaction allowed the one-pot synthesis of tetrahydroisoquinolines after a subsequent internal N-alkylation reaction.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  Strecker reaction; ball milling; mechanochemistry; silica; tetrahydroisoquinolines

Year:  2016        PMID： 27481327     DOI： 10.1002/chem.201603057

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  10 in total

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8.  Bromide-assisted chemoselective Heck reaction of 3-bromoindazoles under high-speed ball-milling conditions: synthesis of axitinib.

Authors:  Jingbo Yu; Zikun Hong; Xinjie Yang; Yu Jiang; Zhijiang Jiang; Weike Su
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9.  A mechanochemical approach to access the proline-proline diketopiperazine framework.

Authors:  Nicolas Pétry; Hafid Benakki; Eric Clot; Pascal Retailleau; Farhate Guenoun; Fatima Asserar; Chakib Sekkat; Thomas-Xavier Métro; Jean Martinez; Frédéric Lamaty
Journal:  Beilstein J Org Chem       Date:  2017-10-19       Impact factor: 2.883

10.  Efficient Enzymatic Hydrolysis of Biomass Hemicellulose in the Absence of Bulk Water.

Authors:  Shaghayegh Ostadjoo; Fabien Hammerer; Karolin Dietrich; Marie-Josée Dumont; Tomislav Friščić; Karine Auclair
Journal:  Molecules       Date:  2019-11-20       Impact factor: 4.411
  10 in total

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