BACKGROUND: Distinct lesion topography in relapsing-remitting multiple sclerosis (RRMS) might be due to different antigen presentation and/or trafficking routes of immune cells into the central nervous system (CNS). OBJECTIVE: To investigate whether distinct lesion patterns in multiple sclerosis (MS) might be associated with a predominance of distinct circulating T-helper cell subset as well as their innate counterparts. METHODS: Flow cytometric analysis of lymphocytes derived from the peripheral blood of patients with exclusively cerebral (n = 20) or predominantly spinal (n = 12) disease manifestation. RESULTS: Patients with exclusively cerebral or preferential spinal lesion manifestation were associated with increased proportions of circulating granulocyte-macrophage colony-stimulating factor (GM-CSF) producing TH1 cells or interleukin (IL)-17-producing TH17 cells, respectively. In contrast, proportions of peripheral IL-17/IL-22-producing lymphoid tissue inducer (LTi), the innate counterpart of TH17 cells, were enhanced in RRMS patients with exclusively cerebral lesion topography. CONCLUSIONS: Distinct T-helper and T-helper-like innate lymphoid cell (ILC) subsets are associated with different lesion topography in RRMS.
BACKGROUND: Distinct lesion topography in relapsing-remitting multiple sclerosis (RRMS) might be due to different antigen presentation and/or trafficking routes of immune cells into the central nervous system (CNS). OBJECTIVE: To investigate whether distinct lesion patterns in multiple sclerosis (MS) might be associated with a predominance of distinct circulating T-helper cell subset as well as their innate counterparts. METHODS: Flow cytometric analysis of lymphocytes derived from the peripheral blood of patients with exclusively cerebral (n = 20) or predominantly spinal (n = 12) disease manifestation. RESULTS:Patients with exclusively cerebral or preferential spinal lesion manifestation were associated with increased proportions of circulating granulocyte-macrophage colony-stimulating factor (GM-CSF) producing TH1 cells or interleukin (IL)-17-producing TH17 cells, respectively. In contrast, proportions of peripheral IL-17/IL-22-producing lymphoid tissue inducer (LTi), the innate counterpart of TH17 cells, were enhanced in RRMS patients with exclusively cerebral lesion topography. CONCLUSIONS: Distinct T-helper and T-helper-like innate lymphoid cell (ILC) subsets are associated with different lesion topography in RRMS.
Authors: Mattias Bronge; Klara Asplund Högelin; Olivia G Thomas; Sabrina Ruhrmann; Claudia Carvalho-Queiroz; Ola B Nilsson; Andreas Kaiser; Manuel Zeitelhofer; Erik Holmgren; Mathias Linnerbauer; Milena Z Adzemovic; Cecilia Hellström; Ivan Jelcic; Hao Liu; Peter Nilsson; Jan Hillert; Lou Brundin; Katharina Fink; Ingrid Kockum; Katarina Tengvall; Roland Martin; Hanna Tegel; Torbjörn Gräslund; Faiez Al Nimer; André Ortlieb Guerreiro-Cacais; Mohsen Khademi; Guro Gafvelin; Tomas Olsson; Hans Grönlund Journal: Sci Adv Date: 2022-04-27 Impact factor: 14.957
Authors: Olga Matveeva; Jeroen F J Bogie; Jerome J A Hendriks; Ralf A Linker; Aiden Haghikia; Markus Kleinewietfeld Journal: Ann N Y Acad Sci Date: 2018-01-27 Impact factor: 5.691
Authors: Jana Freff; Kathrin Schwarte; Lisa Bröker; Judith Bühlmeier; Isabelle Kraft; Dana Öztürk; Anke Hinney; Volker Arolt; Udo Dannlowski; Georg Romer; Bernhard T Baune; Johannes Hebebrand; Manuel Föcker; Judith Alferink Journal: Sci Rep Date: 2021-01-13 Impact factor: 4.379