Sofia Beltrame1, Maximiliano Toscano1, Ezequiel Goldschmidt2, Lucas Garategui1, Alvaro Campero3, Claudio Yampolsky1, Antonio Carrizo1, Pablo Ajler4. 1. Servicio de Neurocirugía, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. 2. Department of Neurological Surgery, University of Pittsburgh, Pensylvania, Estados Unidos. 3. Servicio de Neurocirugía, Hospital Padilla, Tucumán, Argentina. 4. Servicio de Neurocirugía, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. Electronic address: pablo.ajler@hospitalitaliano.org.ar.
Abstract
OBJECTIVE: To present the clinical and radiographic outcomes of 140 patients with pituitary adenomas treated by an endoscopic endonasal approach (EEA) over a period of 4 years. MATERIAL AND METHODS: A retrospective analysis was performed between 2011 and 2014. Pre and post operative MRI, ophtalmological assessment, endocrinological laboratory evaluation and surgical morbidity and mortality were assessed. RESULTS: 57,9% of the patients had functional tumors (n=81), acromegaly being the most frequent sub-type (29.3%). 78.6% of the lesions were macroadenomas (n=110) of which 56.4% (n=62) involved the cavernous sinus, 61 patients presented with visual field defects (44%) of which 50.8% of patients showed improvement after surgery. Gross total removal was achieved in 60% of the cases. Hormonal remission was achieved in the 75% of the patients with functional tumors. The morbidity rate was 15% and one patient died after surgery (mortality 0.7%). CONCLUSION: EEA is a safe and effective tool to treat pituitary adenomas. The main limitation for complete surgical resection is the cavernous sinus invasion.
OBJECTIVE: To present the clinical and radiographic outcomes of 140 patients with pituitary adenomas treated by an endoscopic endonasal approach (EEA) over a period of 4 years. MATERIAL AND METHODS: A retrospective analysis was performed between 2011 and 2014. Pre and post operative MRI, ophtalmological assessment, endocrinological laboratory evaluation and surgical morbidity and mortality were assessed. RESULTS: 57,9% of the patients had functional tumors (n=81), acromegaly being the most frequent sub-type (29.3%). 78.6% of the lesions were macroadenomas (n=110) of which 56.4% (n=62) involved the cavernous sinus, 61 patients presented with visual field defects (44%) of which 50.8% of patients showed improvement after surgery. Gross total removal was achieved in 60% of the cases. Hormonal remission was achieved in the 75% of the patients with functional tumors. The morbidity rate was 15% and one patient died after surgery (mortality 0.7%). CONCLUSION: EEA is a safe and effective tool to treat pituitary adenomas. The main limitation for complete surgical resection is the cavernous sinus invasion.
Authors: James Barger; Matthew Siow; Michael Kader; Katherine Phillips; Girish Fatterpekar; David Kleinberg; David Zagzag; Chandranath Sen; John G Golfinos; Richard Lebowitz; Dimitris G Placantonakis Journal: Surg Neurol Int Date: 2018-02-14
Authors: Mohamed A R Soliman; Sydney Eaton; Elise Quint; Abdullah F Alkhamees; Saba Shahab; Avalon O'Connor; Erika Haberfellner; Jacob Im; Abdurrahim A Elashaal; Francis Ling; Mustafa Elbreki; Tommy Dang; Dante J Morassutti; Abdalla Shamisa Journal: World Neurosurg Date: 2020-04-13 Impact factor: 2.104