Literature DB >> 27480849

Validation of the HIV Tropism Test TROCAI Using the Virological Response to a Short-Term Maraviroc Monotherapy Exposure.

A Gonzalez-Serna1, M Genebat2, M De Luna-Romero2, L Tarancon-Diez2, B Dominguez-Molina2, Y M Pacheco2, M A Muñoz-Fernández3, M Leal2, E Ruiz-Mateos4.   

Abstract

TROCAI is a phenotypic tropism test developed using the virological response to a short-term exposure to maraviroc monotherapy (Maraviroc Clinical Test [MCT]). It was found that with TROCAI, a cutoff of <0.5% of dual/mixed viruses was needed to predict R5 HIV tropism. Here, we have validated TROCAI, using this cutoff, in a new cohort of 42 patients, finding a very high concordance between TROCAI and MCT (98%), and a good concordance (71 to 87%) with other genotypic/phenotypic methods.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 27480849      PMCID： PMC5038326          DOI： 10.1128/AAC.01326-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

Review 1.  Genotypic determination of HIV tropism - clinical and methodological recommendations to guide the therapeutic use of CCR5 antagonists.

Authors:  Eva Poveda; José Alcamí; Roger Paredes; Juan Córdoba; Félix Gutiérrez; Josep María Llibre; Rafael Delgado; Federico Pulido; José Antonio Iribarren; Miguel García Deltoro; José Hernández Quero; Santiago Moreno; Federico García
Journal:  AIDS Rev       Date:  2010 Jul-Sep       Impact factor: 2.500

2.  Long-term immunovirogical effect and tolerability of a maraviroc-containing regimen in routine clinical practice.

Authors:  Miguel Genebat; Ezequiel Ruiz-Mateos; Ildefonso Pulido; Alejandro González-Serna; Antonio García-Pergañeda; Gema Méndez; María Concepción Romero-Sánchez; Sara Ferrando-Martínez; Manuel Leal
Journal:  Curr HIV Res       Date:  2010-09       Impact factor: 1.581

3.  Virological response after short-term CCR5 antagonist exposure in HIV-infected patients: frequency of subjects with virological response and associated factors.

Authors:  Ezequiel Ruiz-Mateos; Alejandro González-Serna; Miguel Genebat; Kawthar Machmach; Francesc Vidal; Angeles Muñoz-Fernández; Sara Ferrando-Martinez; Manuel Leal
Journal:  Antimicrob Agents Chemother       Date:  2011-08-01       Impact factor: 5.191

4.  Variability in the human immunodeficiency virus type 1 gp120 Env protein linked to phenotype-associated changes in the V3 loop.

Authors:  Noah G Hoffman; Francoise Seillier-Moiseiwitsch; JaeHyung Ahn; Jason M Walker; Ronald Swanstrom
Journal:  J Virol       Date:  2002-04       Impact factor: 5.103

5.  HIV-1 dynamics and coreceptor usage in Maraviroc-treated patients with ongoing replication.

Authors:  P Recordon-Pinson; S Raymond; P Bellecave; A G Marcelin; C Soulie; D Descamps; V Calvez; P R Harrigan; H Fleury; J Izopet; B Masquelier
Journal:  Antimicrob Agents Chemother       Date:  2012-12-03       Impact factor: 5.191

6.  Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy.

Authors:  T W Chun; L Stuyver; S B Mizell; L A Ehler; J A Mican; M Baseler; A L Lloyd; M A Nowak; A S Fauci
Journal:  Proc Natl Acad Sci U S A       Date:  1997-11-25       Impact factor: 11.205

7.  Discordance rates between Trofile test and short-term virological response to maraviroc.

Authors:  Miguel Genebat; Ezequiel Ruiz-Mateos; Alejandro González-Serna; Ildefonso Pulido; M Ángeles Muñoz-Fernández; Sara Ferrando-Martínez; Manuel Leal
Journal:  Antiviral Res       Date:  2010-12-04       Impact factor: 5.970

8.  TROCAI (tropism coreceptor assay information): a new phenotypic tropism test and its correlation with Trofile enhanced sensitivity and genotypic approaches.

Authors:  Alejandro Gonzalez-Serna; Manuel Leal; Miguel Genebat; Maria Antonia Abad; Antonio Garcia-Perganeda; Sara Ferrando-Martinez; Ezequiel Ruiz-Mateos
Journal:  J Clin Microbiol       Date:  2010-10-13       Impact factor: 5.948

9.  Recovery of replication-competent HIV despite prolonged suppression of plasma viremia.

Authors:  J K Wong; M Hezareh; H F Günthard; D V Havlir; C C Ignacio; C A Spina; D D Richman
Journal:  Science       Date:  1997-11-14       Impact factor: 47.728

10.  Correlation between the Trofile test and virological response to a short-term maraviroc exposure in HIV-infected patients.

Authors:  Miguel Genebat; Ezequiel Ruiz-Mateos; Juan A León; Alejandro González-Serna; Ildefonso Pulido; Inmaculada Rivas; Sara Ferrando-Martínez; Berta Sánchez; Ma Angeles Muñoz-Fernández; Manuel Leal
Journal:  J Antimicrob Chemother       Date:  2009-08-11       Impact factor: 5.790
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