| Literature DB >> 27480641 |
Sergey V Brodsky1, Amy C Gruszecki2, Kim Fallon3, Melissa A Pasquale-Styles4, Sophia Shaddy5, Vedat Yildiz6, Sarah K Long2, Michelle MacDonell2, Renee L Brideau3, Joanne Keane3, Patricia Allenby5, Iouri Ivanov5, Stephen Moore5, Stephen M Smith5, Taha Sachak5, Matthew Ball5, Keluo Yao5, Iyore James7, Navin Muni5, Rolf F Barth5.
Abstract
With the widespread increase in the incidence of obesity, autopsies on severely and morbidly obese deceased have become common in the USA. Standard reference tables for organ weights provide little or no information on individuals with a body mass index greater than 35 kg/m(2). Although several recent reports have provided organ weights for small numbers of morbidly obese persons who died naturally from a variety of causes, these data may have been affected by comorbidities. Furthermore, they did not provide information relative to differences in organ weight based on gender, age, and race. The aim of the present study was to fill this void by developing reference tables for organ weights of severely and morbidly obese individuals. Our study was based on data from 802 forensic and medical autopsies, including 435 cases of death of natural and 367 of non-natural causes. Organ weights were compared between these groups, and reference ranges were generated. Significant variability was found in organ weights especially among deceased older than 40 years who died naturally, suggesting that comorbidities affect organ weight. Reference tables were compiled for organ weights and morphometric data based on gender, age, and race. Since obesity is a pathological condition affecting organ weight, these reference tables do not reflect normal organ weights but only weight as seen in severely and morbidly obese individuals. They should be useful to pathologists who perform forensic and non-forensic autopsies.Entities:
Keywords: Autopsy; Morbid obesity; Morphometry; Organ weight
Mesh:
Year: 2016 PMID: 27480641 DOI: 10.1007/s00428-016-1994-x
Source DB: PubMed Journal: Virchows Arch ISSN: 0945-6317 Impact factor: 4.064