Literature DB >> 27480641

Morphometric data on severely and morbidly obese deceased, established on forensic and non-forensic autopsies.

Sergey V Brodsky1, Amy C Gruszecki2, Kim Fallon3, Melissa A Pasquale-Styles4, Sophia Shaddy5, Vedat Yildiz6, Sarah K Long2, Michelle MacDonell2, Renee L Brideau3, Joanne Keane3, Patricia Allenby5, Iouri Ivanov5, Stephen Moore5, Stephen M Smith5, Taha Sachak5, Matthew Ball5, Keluo Yao5, Iyore James7, Navin Muni5, Rolf F Barth5.   

Abstract

With the widespread increase in the incidence of obesity, autopsies on severely and morbidly obese deceased have become common in the USA. Standard reference tables for organ weights provide little or no information on individuals with a body mass index greater than 35 kg/m(2). Although several recent reports have provided organ weights for small numbers of morbidly obese persons who died naturally from a variety of causes, these data may have been affected by comorbidities. Furthermore, they did not provide information relative to differences in organ weight based on gender, age, and race. The aim of the present study was to fill this void by developing reference tables for organ weights of severely and morbidly obese individuals. Our study was based on data from 802 forensic and medical autopsies, including 435 cases of death of natural and 367 of non-natural causes. Organ weights were compared between these groups, and reference ranges were generated. Significant variability was found in organ weights especially among deceased older than 40 years who died naturally, suggesting that comorbidities affect organ weight. Reference tables were compiled for organ weights and morphometric data based on gender, age, and race. Since obesity is a pathological condition affecting organ weight, these reference tables do not reflect normal organ weights but only weight as seen in severely and morbidly obese individuals. They should be useful to pathologists who perform forensic and non-forensic autopsies.

Entities:  

Keywords:  Autopsy; Morbid obesity; Morphometry; Organ weight

Mesh:

Year:  2016        PMID: 27480641     DOI: 10.1007/s00428-016-1994-x

Source DB:  PubMed          Journal:  Virchows Arch        ISSN: 0945-6317            Impact factor:   4.064


  16 in total

1.  Organ weight in 684 adult autopsies: new tables for a Caucasoid population.

Authors:  G L de la Grandmaison; I Clairand; M Durigon
Journal:  Forensic Sci Int       Date:  2001-06-15       Impact factor: 2.395

2.  Derivation of new reference tables for human heart weights in light of increasing body mass index.

Authors:  Kezia Gaitskell; Rafael Perera; Elizabeth J Soilleux
Journal:  J Clin Pathol       Date:  2010-11-07       Impact factor: 3.411

3.  Correlation of internal organ weight with body weight and length in normal Thai adults.

Authors:  Piyanun Mathuramon; Thamrong Chirachariyavej; A V M Vichan Peonim; Mana Rochanawutanon
Journal:  J Med Assoc Thai       Date:  2009-02

Review 4.  Assessment and definition of lean body mass deficiency in the elderly.

Authors:  M J Müller; C Geisler; M Pourhassan; C-C Glüer; A Bosy-Westphal
Journal:  Eur J Clin Nutr       Date:  2014-08-20       Impact factor: 4.016

5.  New reference tables and user-friendly Internet application for predicted heart weights.

Authors:  Jessica Vanhaebost; Mohamed Faouzi; Patrice Mangin; Katarzyna Michaud
Journal:  Int J Legal Med       Date:  2014-01-11       Impact factor: 2.686

6.  Morbid obesity rates continue to rise rapidly in the United States.

Authors:  R Sturm; A Hattori
Journal:  Int J Obes (Lond)       Date:  2013-06       Impact factor: 5.095

7.  Organ weight changes associated with body mass index determined from a medical autopsy population.

Authors:  Rakesh Mandal; Agnes G Loeffler; Shahriar Salamat; Michael K Fritsch
Journal:  Am J Forensic Med Pathol       Date:  2012-12       Impact factor: 0.921

8.  Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee.

Authors: 
Journal:  World Health Organ Tech Rep Ser       Date:  1995

9.  Anthropometric reference data for children and adults: United States, 2007-2010.

Authors:  Cheryl D Fryar; Qiuping Gu; Cynthia L Ogden
Journal:  Vital Health Stat 11       Date:  2012-10

Review 10.  Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis.

Authors:  Katherine M Flegal; Brian K Kit; Heather Orpana; Barry I Graubard
Journal:  JAMA       Date:  2013-01-02       Impact factor: 56.272

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  2 in total

Review 1.  The Importance of the Autopsy in Medicine: Perspectives of Pathology Colleagues.

Authors:  Louis Maximilian Buja; Rolf F Barth; Gerhard R Krueger; Sergey V Brodsky; Robert L Hunter
Journal:  Acad Pathol       Date:  2019-03-10

2.  Repository Describing the Anatomical, Physiological, and Biological Changes in an Obese Population to Inform Physiologically Based Pharmacokinetic Models.

Authors:  Mattia Berton; Sara Bettonte; Felix Stader; Manuel Battegay; Catia Marzolini
Journal:  Clin Pharmacokinet       Date:  2022-06-14       Impact factor: 5.577

  2 in total

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