Niels Verburg1, Petra J W Pouwels, Ronald Boellaard, Frederik Barkhof, Otto S Hoekstra, Jaap C Reijneveld, W Peter Vandertop, Pieter Wesseling, Philip C de Witt Hamer. 1. *Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, the Netherlands; ‡Department of Physics & Medical Technology, VU University Medical Center, Amsterdam, the Netherlands; §Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands; ¶Department of Neurology, VU University Medical Center, Amsterdam, the Netherlands; ‖Department of Pathology, VU University Medical Center, Amsterdam, the Netherlands; #Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands.
Abstract
BACKGROUND: Glioma imaging, used for diagnostics, treatment planning, and follow-up, is currently based on standard magnetic resonance imaging (MRI) modalities (T1 contrast-enhancement for gadolinium-enhancing gliomas and T2 fluid-attenuated inversion recovery hyperintensity for nonenhancing gliomas). The diagnostic accuracy of these techniques for the delineation of gliomas is suboptimal. OBJECTIVE: To assess the diagnostic accuracy of advanced neuroimaging compared with standard MRI modalities for the detection of diffuse glioma infiltration within the brain. METHODS: A monocenter, prospective, diagnostic observational study in adult patients with a newly diagnosed, diffuse infiltrative glioma undergoing resective glioma surgery. Forty patients will be recruited in 3 years. Advanced neuroimaging will be added to the standard preoperative MRI. Serial neuronavigated biopsies in and around the glioma boundaries, obtained immediately preceding resective surgery, will provide histopathologic and molecular characteristics of the regions of interest, enabling comparison with quantitative measurements in the imaging modalities at the same biopsy sites. DISCUSSION: In this clinical study, we determine the diagnostic accuracy of advanced imaging in addition to standard MRI to delineate glioma. The results of our study can be valuable for the development of an improved standard imaging protocol for glioma treatment. EXPECTED OUTCOME: We hypothesize that a combination of positron emission tomography, MR spectroscopy, and standard MRI will have a superior accuracy for glioma delineation compared with standard MRI alone. In addition, we anticipate that advanced imaging will correlate with the histopathologic and molecular characteristics of glioma. ABBREVIATIONS: CHO, [11C-]CholineCRF, case report formsFET, [18F-]Fluoroethyl-tyrosineFLAIR, fluid-attenuated inversion recoveryMETC, Medical Ethical CommitteeMRS, magnetic resonance spectroscopyPET, positron emission tomographyVUmc, VU University Medical Center.
BACKGROUND:Glioma imaging, used for diagnostics, treatment planning, and follow-up, is currently based on standard magnetic resonance imaging (MRI) modalities (T1 contrast-enhancement for gadolinium-enhancing gliomas and T2 fluid-attenuated inversion recovery hyperintensity for nonenhancing gliomas). The diagnostic accuracy of these techniques for the delineation of gliomas is suboptimal. OBJECTIVE: To assess the diagnostic accuracy of advanced neuroimaging compared with standard MRI modalities for the detection of diffuse glioma infiltration within the brain. METHODS: A monocenter, prospective, diagnostic observational study in adult patients with a newly diagnosed, diffuse infiltrative glioma undergoing resective glioma surgery. Forty patients will be recruited in 3 years. Advanced neuroimaging will be added to the standard preoperative MRI. Serial neuronavigated biopsies in and around the glioma boundaries, obtained immediately preceding resective surgery, will provide histopathologic and molecular characteristics of the regions of interest, enabling comparison with quantitative measurements in the imaging modalities at the same biopsy sites. DISCUSSION: In this clinical study, we determine the diagnostic accuracy of advanced imaging in addition to standard MRI to delineate glioma. The results of our study can be valuable for the development of an improved standard imaging protocol for glioma treatment. EXPECTED OUTCOME: We hypothesize that a combination of positron emission tomography, MR spectroscopy, and standard MRI will have a superior accuracy for glioma delineation compared with standard MRI alone. In addition, we anticipate that advanced imaging will correlate with the histopathologic and molecular characteristics of glioma. ABBREVIATIONS: CHO, [11C-]CholineCRF, case report formsFET, [18F-]Fluoroethyl-tyrosineFLAIR, fluid-attenuated inversion recoveryMETC, Medical Ethical CommitteeMRS, magnetic resonance spectroscopyPET, positron emission tomographyVUmc, VU University Medical Center.
Authors: Kyle Wang; Brandon T Mullins; Aaron D Falchook; Jun Lian; Kelei He; Dinggang Shen; Michael Dance; Weili Lin; Tiffany M Sills; Shiva K Das; Benjamin Y Huang; Bhishamjit S Chera Journal: Front Oncol Date: 2017-01-23 Impact factor: 6.244
Authors: Thomas Koopman; Niels Verburg; Robert C Schuit; Petra J W Pouwels; Pieter Wesseling; Albert D Windhorst; Otto S Hoekstra; Philip C de Witt Hamer; Adriaan A Lammertsma; Ronald Boellaard; Maqsood Yaqub Journal: EJNMMI Res Date: 2018-07-31 Impact factor: 3.138
Authors: Thomas Koopman; Niels Verburg; Petra Jw Pouwels; Pieter Wesseling; Otto S Hoekstra; Philip C De Witt Hamer; Adriaan A Lammertsma; Maqsood Yaqub; Ronald Boellaard Journal: J Cereb Blood Flow Metab Date: 2019-05-24 Impact factor: 6.200
Authors: Niels Verburg; Thomas Koopman; Maqsood M Yaqub; Otto S Hoekstra; Adriaan A Lammertsma; Frederik Barkhof; Petra J W Pouwels; Jaap C Reijneveld; Jan J Heimans; Annemarie J M Rozemuller; Anne M E Bruynzeel; Frank Lagerwaard; William P Vandertop; Ronald Boellaard; Pieter Wesseling; Philip C de Witt Hamer Journal: Neuro Oncol Date: 2020-03-05 Impact factor: 12.300
Authors: Patricia Clement; Thomas Booth; Fran Borovečki; Kyrre E Emblem; Patrícia Figueiredo; Lydiane Hirschler; Radim Jančálek; Vera C Keil; Camille Maumet; Yelda Özsunar; Cyril Pernet; Jan Petr; Joana Pinto; Marion Smits; Esther A H Warnert Journal: J Med Biol Eng Date: 2020-12-03 Impact factor: 2.213
Authors: Niels Verburg; Floris P Barthel; Kevin J Anderson; Kevin C Johnson; Thomas Koopman; Maqsood M Yaqub; Otto S Hoekstra; Adriaan A Lammertsma; Frederik Barkhof; Petra J W Pouwels; Jaap C Reijneveld; Annemieke J M Rozemuller; Jeroen A M Beliën; Ronald Boellaard; Michael D Taylor; Sunit Das; Joseph F Costello; William Peter Vandertop; Pieter Wesseling; Philip C de Witt Hamer; Roel G W Verhaak Journal: Neuro Oncol Date: 2021-12-01 Impact factor: 12.300