| Literature DB >> 27478962 |
Debanjan Dutta1, Riya Mukherjee1, Mousumi Patra1, Milon Banik1, Rakhi Dasgupta1, Manabendra Mukherjee2, Tarakdas Basu3.
Abstract
Cerium oxide nanoparticle (CeONP) of size 2-3nm was synthesized by a new, simple and green method at ambient temperature, using cerium nitrate as prime precursor and Aloe vera leaf extract as stabilizing agent. Of the two oxidation states (+3) and (+4) of cerium, it was dominantly present in (+3) state in CeONP and cyclic conversion of Ce(III)O→Ce(IV)O→Ce(III)O by reaction with H2O2 implied uninterrupted antioxidant property of CeONP. Moreover, the higher oxygen defect in the crystal lattice produced particles with higher antioxidant activity. CeONP was found to neutralize the deleterious effects of H2O2 viz., cell death, generation of intracellular reactive oxygen species and loss of connectivity in mouse neural cells. Therefore, CeONP might have potential use in future as an anti-oxidant drug.Entities:
Keywords: Aloe-vera extract; Anti-oxidant activity; Cerium oxide nanoparticles; Green synthesis; Mouse neural cells
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Year: 2016 PMID： 27478962 DOI： 10.1016/j.colsurfb.2016.07.045
Source DB: PubMed Journal: Colloids Surf B Biointerfaces ISSN： 0927-7765 Impact factor: 5.268