| Literature DB >> 27477893 |
A H Lima1, C N Alves, R Prasad, J Lameira.
Abstract
Herein, we used computer simulation to evaluate the free energy activation barriers of the first and second methyl transfer for native SET8 PKMT and its Y334F mutant. The results suggest that the origin of SET8 catalytic power is mainly due to electrostatic preorganization.Entities:
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Year: 2016 PMID： 27477893 DOI： 10.1039/c6mb00414h
Source DB: PubMed Journal: Mol Biosyst ISSN： 1742-2051