I Eser1, N Yologlu2, C Baydemir3, M Aydogan2. 1. Division of Pediatric Allergy and Immunology, Kocaeli University, 41380 Umuttepe, Kocaeli, Turkey. Electronic address: dreserisil@hotmail.com. 2. Division of Pediatric Allergy and Immunology, Kocaeli University, 41380 Umuttepe, Kocaeli, Turkey. 3. Department of Biostatistics and Medical Informatics, Kocaeli University, Kocaeli, Turkey.
Abstract
BACKGROUND: There are few studies in children on the natural course of chronic spontaneous urticaria (CSU) because of its relative infrequency in childhood. OBJECTIVE: To estimate the rate of remission and evaluate the prognostic factors in children with CSU. METHOD: A total of 52 children with CSU were prospectively followed over a period of three years. RESULTS: The remission rates at 12 months and 36 months were 32.7% and 48.1%. The mean duration of disease at the first visit in the non-remission group was higher than in the remission group at the end of the study (P=0.016). The remission rate of the patients who had been treated by standard dose antihistamine was higher than that of the patients who had been treated with the high-dose antihistamine and combination medications (P=0.004, P<0.001). The treatment steps were independent prognostic factors for remission by logistic regression analysis. CONCLUSION: Our study indicates that urticaria controlled by a standard dose of antihistamine can predict a good prognosis independently from disease duration at first visit.
BACKGROUND: There are few studies in children on the natural course of chronic spontaneous urticaria (CSU) because of its relative infrequency in childhood. OBJECTIVE: To estimate the rate of remission and evaluate the prognostic factors in children with CSU. METHOD: A total of 52 children with CSU were prospectively followed over a period of three years. RESULTS: The remission rates at 12 months and 36 months were 32.7% and 48.1%. The mean duration of disease at the first visit in the non-remission group was higher than in the remission group at the end of the study (P=0.016). The remission rate of the patients who had been treated by standard dose antihistamine was higher than that of the patients who had been treated with the high-dose antihistamine and combination medications (P=0.004, P<0.001). The treatment steps were independent prognostic factors for remission by logistic regression analysis. CONCLUSION: Our study indicates that urticaria controlled by a standard dose of antihistamine can predict a good prognosis independently from disease duration at first visit.
Authors: Onyinye I Iweala; Christopher Copenhaver; Eveline Y Wu; Timothy P Moran Journal: Ann Allergy Asthma Immunol Date: 2017-11-20 Impact factor: 6.347