Literature DB >> 2747656

The parathyroid hormone-related protein associated with malignancy is secreted by neuroendocrine tumors.

L J Deftos1, A F Gazdar, K Ikeda, A E Broadus.   

Abstract

We have demonstrated the production of the PTH-related protein (PTHrP) associated with hypercalcemia of malignancy by human neuroendocrine cell lines that also produce calcitonin gene products and chromogranin A. PTHrP was demonstrable in the cells by immunocytochemistry and immunoassay and Northern analysis of the cells revealed the presence of multiple mRNAs for PTHrP. The cell lines also secreted PTHrP in a regulated fashion, with the most potent secretagogue being phorbol. Thus, PTHrP is secreted by neuroendocrine cells and it may have neuroectodermal lineage. The coexpression of calcitonin gene products and chromogranin A, also neuroendocrine, with PTHRP may influence its secretion and ultimate biological effects in vivo.

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Year:  1989        PMID： 2747656     DOI： 10.1210/mend-3-3-503

Source DB:  PubMed          Journal:  Mol Endocrinol        ISSN： 0888-8809


  14 in total

1.  Parathyroid hormone-related protein production by adenocarcinoma in Barrett's esophagus patient with dermatomyositis.

Authors:  S Tanabe; H Mitomi; M Sada; I Yamazaki; T Akaboshi; I Okayasu; T Kameya; K Saigenji
Journal:  Dig Dis Sci       Date:  2001-07       Impact factor: 3.199

2.  [Ectopic hormone secretion by neuroendocrine tumors].

Authors:  C Hubold; G Brabant
Journal:  Internist (Berl)       Date:  2012-02       Impact factor: 0.743

3.  Type I collagen and divalent cation shifts disrupt cell-cell adhesion, increase migration, and decrease PTHrP, IL-6, and IL-8 expression in pancreatic cancer cells.

Authors:  John J Grzesiak; Kathy C Smith; Cheryl Chalberg; Douglas W Burton; Leonard J Deftos; Michael Bouvet
Journal:  Int J Gastrointest Cancer       Date:  2005

Review 4.  Parathyroid-hormone-related peptides. A new class of multifunctional proteins.

Authors:  T Roskams; V Desmet
Journal:  Am J Pathol       Date:  1997-03       Impact factor: 4.307

5.  Immunohistochemical localization of parathyroid hormone-related protein (PTHrP) and serum PTHrP in normocalcemic patients with oral squamous cell carcinoma.

Authors:  Makoto Tsuchimochi; Ayako Kameta; Mikiko Sue; Masataka Katagiri
Journal:  Odontology       Date:  2005-09       Impact factor: 2.634

Review 6.  Parathyroid hormone-like peptide.

Authors:  Daniel J Drucker
Journal:  Endocr Pathol       Date:  1991-03       Impact factor: 3.943

7.  Comparative tissue distribution of the processing enzymes "prohormone thiol protease," and prohormone convertases 1 and 2, in human PTHrP-producing cell lines and mammalian neuroendocrine tissues.

Authors:  L J Deftos; D Burton; R H Hastings; R Terkeltaub; V Y Hook
Journal:  Endocrine       Date:  2001-07       Impact factor: 3.633

8.  Parathyroid hormone-related protein in tissues of the emerging frog (Rana temporaria): immunohistochemistry and in situ hybridisation.

Authors:  J A Danks; J C McHale; T J Martin; P M Ingleton
Journal:  J Anat       Date:  1997-02       Impact factor: 2.610

9.  Parathyroid hormone-related peptide gene is expressed in the mammalian central nervous system.

Authors:  E C Weir; M L Brines; K Ikeda; W J Burtis; A E Broadus; R J Robbins
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

10.  Parathyroid hormone-like protein is a secretory product of atrial myocytes.

Authors:  L J Deftos; D W Burton; D W Brandt
Journal:  J Clin Invest       Date:  1993-08       Impact factor: 14.808
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